TY - JOUR
T1 - Review Article
T2 - CARDIOVASCULAR DISORDERS ASSOCIATED WITH ACROMEGALY: An Update
AU - Sherin, Rinsha Pv
AU - Vietor, Nicole O
AU - Usman, Aqueel
AU - Hoang, Thanh D
AU - Shakir, Mohamed Km
N1 - Copyright © 2024. Published by Elsevier Inc.
PY - 2024/9/25
Y1 - 2024/9/25
N2 - The most common causes of increased cardiovascular mortality in acromegaly are due to cardiac arrhythmias and sudden cardiac death. Acromegalic cardiomyopathy, is defined as concentric biventricular hypertrophy and diastolic dysfunction when other cardiac diseases like hypertension, diabetes mellitus, and arrhythmias related cardiac disorders have been excluded. This also contributes to significant morbidity and mortality in these patients. The main risk factors contributing to the development of cardiomyopathy include advancing age, disease duration and body mass index (BMI). The duration of GH excess rather than the degree of hormone elevation is more closely associated with the development of biventricular enlargement, diastolic dysfunction, heart failure, and valvular disease. Additionally, other cardiovascular disorders such as coronary artery disease, arrhythmias, valvular heart diseases, systemic hypertension, atherosclerosis, and rarely congestive cardiac failure are also involved in the shortened life span of these patients especially if poorly controlled. Biochemical control of acromegaly with the recently available multimodal treatment along with better management of cardiovascular co-morbidities has improved the morbidity and mortality rates of patients with acromegaly. However, with the recent advances in the treatment of acromegaly neoplastic causes presently remain as the main leading cause of death in these patients.
AB - The most common causes of increased cardiovascular mortality in acromegaly are due to cardiac arrhythmias and sudden cardiac death. Acromegalic cardiomyopathy, is defined as concentric biventricular hypertrophy and diastolic dysfunction when other cardiac diseases like hypertension, diabetes mellitus, and arrhythmias related cardiac disorders have been excluded. This also contributes to significant morbidity and mortality in these patients. The main risk factors contributing to the development of cardiomyopathy include advancing age, disease duration and body mass index (BMI). The duration of GH excess rather than the degree of hormone elevation is more closely associated with the development of biventricular enlargement, diastolic dysfunction, heart failure, and valvular disease. Additionally, other cardiovascular disorders such as coronary artery disease, arrhythmias, valvular heart diseases, systemic hypertension, atherosclerosis, and rarely congestive cardiac failure are also involved in the shortened life span of these patients especially if poorly controlled. Biochemical control of acromegaly with the recently available multimodal treatment along with better management of cardiovascular co-morbidities has improved the morbidity and mortality rates of patients with acromegaly. However, with the recent advances in the treatment of acromegaly neoplastic causes presently remain as the main leading cause of death in these patients.
U2 - 10.1016/j.eprac.2024.09.014
DO - 10.1016/j.eprac.2024.09.014
M3 - Review article
C2 - 39332498
SN - 1530-891X
JO - Endocrine Practice
JF - Endocrine Practice
ER -