Review for Disease of the Year: Epidemiology of HLA-B27 Associated Ocular Disorders

Laura J. Kopplin, George Mount, Eric B. Suhler*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Acute anterior uveitis is generally recognized as the most common form of uveitis. An association with HLA-B27 is seen in approximately half of cases of acute anterior uveitis. The prevalence of HLA-B27 varies widely between ethnic populations, with an approximate 8–10% prevalence in non-Hispanic whites and lower prevalence in Mexican- (4%) and African- (2–4%) Americans. A group of systemic inflammatory diseases, the spondyloarthropathies, similarly demonstrates a strong association with HLA-B27. The strength of association varies, depending on the specific spondyloarthropathy, with the strongest association found in patients with ankylosing spondylitis. The majority of patients with HLA-B27 associated uveitis will have an underlying spondyloarthropathy. Suspicion for HLA-B27 associated uveitis should prompt a careful clinical history to assess for features of a spondyloarthropathy as the characteristics of any associated uveitis may vary.

Original languageEnglish
Pages (from-to)470-475
Number of pages6
JournalOcular Immunology and Inflammation
Issue number4
StatePublished - 3 Jul 2016
Externally publishedYes


  • Acute anterior uveitis
  • HLA-B27
  • epidemiology
  • iritis
  • spondyloarthropathy


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