Review: Nitric Oxide, Sepsis, and Arginine Metabolism

Edward Kelly*, Timothy R. Billiar, Sidney M. Morris

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Nitric oxide is one of the most versatile molecules produced by mammalian cells. Its role in sepsis and inflammation has been the subject of intense investigation since its discovery as a cell product in 1987. The role of arginine in sepsis and trauma has also received considerable attention, but most of the earlier studies on arginine preceded the studies on nitric oxide and the discovery that arginine serves as the nitrogen donor for nitric oxide synthesis. This review will explore the role that nitric oxide plays in sepsis and the effects of arginine metabolism on nitric oxide synthesis. (Journal of Parenteral and Enteral Nutrition 19:234-238, 1995).

Original languageEnglish
Pages (from-to)234-238
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Issue number3
StatePublished - May 1995
Externally publishedYes


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