Role of digitalis-like substance in the hypertension of streptozotocin- induced diabetes and simulated weightlessness in rats

M. B. Pamnani; S. Chen; F. J. Haddy; C. Yuan; Z. Mo

doi:10.3109/10641969809053229

Role of digitalis-like substance in the hypertension of streptozotocin- induced diabetes and simulated weightlessness in rats

M. B. Pamnani^*, S. Chen, F. J. Haddy, C. Yuan, Z. Mo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We have examined the role of plasma Na⁺-K⁺ pump inhibitor (SPI) in the hypertension of streptozotocin induced insulin dependent diabetes (IDDM) in reduced renal mass rats. The increase in blood pressure (BP) was associated with an increase in extracellular fluid volume (ECFV), and SPI and a decrease in myocardial Na⁺,K⁺ATPase (NKA) activity, suggesting that increased SPI, which inhibits cardiovascular muscle (CVM) cell NKA activity, may be involved in the mechanism of IDDM-hypertension. In a second study, using prolonged suspension resulted in a decrease in cardiac NKA activity, suggesting that cardiovascular deconditioning following space flight might in part result from insufficient SPI.

Original language	English
Pages (from-to)	509-521
Number of pages	13
Journal	Clinical and Experimental Hypertension
Volume	20
Issue number	5-6
DOIs	https://doi.org/10.3109/10641969809053229
State	Published - 1998
Externally published	Yes

Keywords

Diabetes mellitus
Endogenous digitalis-like substance
Hypertension
Rats
Reduced renal mass
Simulated weightlessness
Streptozotocin

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10.3109/10641969809053229

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title = "Role of digitalis-like substance in the hypertension of streptozotocin- induced diabetes and simulated weightlessness in rats",

abstract = "We have examined the role of plasma Na+-K+ pump inhibitor (SPI) in the hypertension of streptozotocin induced insulin dependent diabetes (IDDM) in reduced renal mass rats. The increase in blood pressure (BP) was associated with an increase in extracellular fluid volume (ECFV), and SPI and a decrease in myocardial Na+,K+ATPase (NKA) activity, suggesting that increased SPI, which inhibits cardiovascular muscle (CVM) cell NKA activity, may be involved in the mechanism of IDDM-hypertension. In a second study, using prolonged suspension resulted in a decrease in cardiac NKA activity, suggesting that cardiovascular deconditioning following space flight might in part result from insufficient SPI.",

keywords = "Diabetes mellitus, Endogenous digitalis-like substance, Hypertension, Rats, Reduced renal mass, Simulated weightlessness, Streptozotocin",

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AU - Pamnani, M. B.

AU - Chen, S.

AU - Haddy, F. J.

AU - Yuan, C.

AU - Mo, Z.

PY - 1998

Y1 - 1998

N2 - We have examined the role of plasma Na+-K+ pump inhibitor (SPI) in the hypertension of streptozotocin induced insulin dependent diabetes (IDDM) in reduced renal mass rats. The increase in blood pressure (BP) was associated with an increase in extracellular fluid volume (ECFV), and SPI and a decrease in myocardial Na+,K+ATPase (NKA) activity, suggesting that increased SPI, which inhibits cardiovascular muscle (CVM) cell NKA activity, may be involved in the mechanism of IDDM-hypertension. In a second study, using prolonged suspension resulted in a decrease in cardiac NKA activity, suggesting that cardiovascular deconditioning following space flight might in part result from insufficient SPI.

AB - We have examined the role of plasma Na+-K+ pump inhibitor (SPI) in the hypertension of streptozotocin induced insulin dependent diabetes (IDDM) in reduced renal mass rats. The increase in blood pressure (BP) was associated with an increase in extracellular fluid volume (ECFV), and SPI and a decrease in myocardial Na+,K+ATPase (NKA) activity, suggesting that increased SPI, which inhibits cardiovascular muscle (CVM) cell NKA activity, may be involved in the mechanism of IDDM-hypertension. In a second study, using prolonged suspension resulted in a decrease in cardiac NKA activity, suggesting that cardiovascular deconditioning following space flight might in part result from insufficient SPI.

KW - Diabetes mellitus

KW - Endogenous digitalis-like substance

KW - Hypertension

KW - Rats

KW - Reduced renal mass

KW - Simulated weightlessness

KW - Streptozotocin

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JF - Clinical and Experimental Hypertension

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Role of digitalis-like substance in the hypertension of streptozotocin- induced diabetes and simulated weightlessness in rats

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