Role of extracellular factors in axon regeneration in the CNS: Implications for therapy

Noreen M. Gervasi; Jessica C.F. Kwok; James W. Fawcett

doi:10.2217/17460751.3.6.907

Role of extracellular factors in axon regeneration in the CNS: Implications for therapy

Noreen M. Gervasi^*, Jessica C.F. Kwok, James W. Fawcett

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

The glial scar that forms after an injury to the CNS contains molecules that are inhibitory to axon growth. Understanding of the mechanisms of inhibition has allowed the development of therapeutic strategies aimed at promoting axon regeneration. Promising results have been obtained in animal models, and some therapies are undergoing clinical trials. This offers great hope for achievement of functional recovery after CNS injury.

Original language	English
Pages (from-to)	907-923
Number of pages	17
Journal	Regenerative Medicine
Volume	3
Issue number	6
DOIs	https://doi.org/10.2217/17460751.3.6.907
State	Published - 2008
Externally published	Yes

Keywords

Axon
CNS
Chondroitin sulfate proteoglycans
Extracellular matrix
Matrix metaloproteases
Myelin-associated glycoprotein
Nogo
Semaphorin
Spinal cord injury
Tenascin

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title = "Role of extracellular factors in axon regeneration in the CNS: Implications for therapy",

abstract = "The glial scar that forms after an injury to the CNS contains molecules that are inhibitory to axon growth. Understanding of the mechanisms of inhibition has allowed the development of therapeutic strategies aimed at promoting axon regeneration. Promising results have been obtained in animal models, and some therapies are undergoing clinical trials. This offers great hope for achievement of functional recovery after CNS injury.",

keywords = "Axon, CNS, Chondroitin sulfate proteoglycans, Extracellular matrix, Matrix metaloproteases, Myelin-associated glycoprotein, Nogo, Semaphorin, Spinal cord injury, Tenascin",

author = "Gervasi, {Noreen M.} and Kwok, {Jessica C.F.} and Fawcett, {James W.}",

year = "2008",

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T2 - Implications for therapy

AU - Gervasi, Noreen M.

AU - Kwok, Jessica C.F.

AU - Fawcett, James W.

PY - 2008

Y1 - 2008

N2 - The glial scar that forms after an injury to the CNS contains molecules that are inhibitory to axon growth. Understanding of the mechanisms of inhibition has allowed the development of therapeutic strategies aimed at promoting axon regeneration. Promising results have been obtained in animal models, and some therapies are undergoing clinical trials. This offers great hope for achievement of functional recovery after CNS injury.

AB - The glial scar that forms after an injury to the CNS contains molecules that are inhibitory to axon growth. Understanding of the mechanisms of inhibition has allowed the development of therapeutic strategies aimed at promoting axon regeneration. Promising results have been obtained in animal models, and some therapies are undergoing clinical trials. This offers great hope for achievement of functional recovery after CNS injury.

KW - Axon

KW - CNS

KW - Chondroitin sulfate proteoglycans

KW - Extracellular matrix

KW - Matrix metaloproteases

KW - Myelin-associated glycoprotein

KW - Nogo

KW - Semaphorin

KW - Spinal cord injury

KW - Tenascin

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U2 - 10.2217/17460751.3.6.907

DO - 10.2217/17460751.3.6.907

M3 - Review article

C2 - 18947312

AN - SCOPUS:58149107226

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SP - 907

EP - 923

JO - Regenerative Medicine

JF - Regenerative Medicine

IS - 6

ER -

Role of extracellular factors in axon regeneration in the CNS: Implications for therapy

Abstract

Keywords

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