Role of HIV-1 envelope glycoproteins conformation and accessory proteins on ADCC responses

Maxime Veillette, Jonathan Richard, Marzena Pazgier, George K. Lewis, Matthew S. Parsons, Andrés Finzi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The role of antibody Fc-mediated effector functions in controlling or preventing infections by human immunodeficiency type 1 (HIV-1) and simian immunodeficiency (SIV) viruses has been recently highlighted in multiple studies. One of those effector functions, antibody-dependent cellular cytotoxicity (ADCC) was suggested as correlating with decreased HIV-1 acquisition risk in the recent Thai RV144 vaccine trial. RV144-elicited antibodies with potent ADCC activity were recently found to recognize HIV envelope (Env) epitopes exposed upon Env-CD4 interaction. However, HIV-1 efficiently limits the exposure of those epitopes by strongly downregulating CD4 by both Nef and Vpu accessory proteins, as well as indirectly preventing the accumulation of Env at the cell surface by Vpu-mediated BST-2 antagonism. These accessory proteins were thus proposed to play a critical role in decreasing the susceptibility of HIVinfected cells to elimination by ADCC. In this review we will summarize these recent findings and discuss the critical role that HIV-1 envelope glycoproteins conformation plays on ADCC responses, how these responses can be measured in the laboratory, the role of HIV-1-transmission on ADCC responses and how this knowledge can be used to develop new strategies aimed at targeting HIV-1-infected cells.

Original languageEnglish
Pages (from-to)9-23
Number of pages15
JournalCurrent HIV Research
Issue number1
StatePublished - 2016
Externally publishedYes


  • ADCC
  • BST-2
  • CD4
  • Envelope glycoproteins
  • Gp120
  • Gp41
  • HIV-1
  • Nef
  • Non-neutralizing antibodies
  • Vpu


Dive into the research topics of 'Role of HIV-1 envelope glycoproteins conformation and accessory proteins on ADCC responses'. Together they form a unique fingerprint.

Cite this