Role of nitric oxide chemistry in cancer treatment

D. A. Wink*, Y. Vodovotz, J. A. Cook, M. C. Krishna, S. Kim, D. Coffin, W. DeGraff, A. M. Deluca, J. Liebmann, J. B. Mitchell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Over the last decade the role of nitric oxide (NO) in various disease states has become apparent. In cancer, NO plays a variety of roles which are at times contradictory. On one hand, NO is involved in different etiological mechanisms as well as promoting tumor growth. Yet, NO derived from leukocytes plays a seminal role in their tumoricidal activity. In cancer treatment, NO also has diverse effects. Whereas in vitro, NO can enhance the cytotoxic efficacy of some chemotherapeutic agents as well as radiation, NO donors can provide whole body protection against these same agents. This manuscript will discuss some mechanisms involved with NO and cancer treatment modalities and the potential application of these findings to cancer therapy.

Original languageEnglish
Pages (from-to)948-957
Number of pages10
Issue number7
StatePublished - Jul 1998
Externally publishedYes


Dive into the research topics of 'Role of nitric oxide chemistry in cancer treatment'. Together they form a unique fingerprint.

Cite this