Role of nitric oxide chemistry in cancer treatment

D. A. Wink; Y. Vodovotz; J. A. Cook; M. C. Krishna; S. Kim; D. Coffin; W. DeGraff; A. M. Deluca; J. Liebmann; J. B. Mitchell

Role of nitric oxide chemistry in cancer treatment

D. A. Wink^*, Y. Vodovotz, J. A. Cook, M. C. Krishna, S. Kim, D. Coffin, W. DeGraff, A. M. Deluca, J. Liebmann, J. B. Mitchell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Over the last decade the role of nitric oxide (NO) in various disease states has become apparent. In cancer, NO plays a variety of roles which are at times contradictory. On one hand, NO is involved in different etiological mechanisms as well as promoting tumor growth. Yet, NO derived from leukocytes plays a seminal role in their tumoricidal activity. In cancer treatment, NO also has diverse effects. Whereas in vitro, NO can enhance the cytotoxic efficacy of some chemotherapeutic agents as well as radiation, NO donors can provide whole body protection against these same agents. This manuscript will discuss some mechanisms involved with NO and cancer treatment modalities and the potential application of these findings to cancer therapy.

Original language	English
Pages (from-to)	948-957
Number of pages	10
Journal	Biokhimiya
Volume	63
Issue number	7
State	Published - Jul 1998
Externally published	Yes

Cite this

@article{0768a9a84c044426abb471c3084ab5a1,

title = "Role of nitric oxide chemistry in cancer treatment",

abstract = "Over the last decade the role of nitric oxide (NO) in various disease states has become apparent. In cancer, NO plays a variety of roles which are at times contradictory. On one hand, NO is involved in different etiological mechanisms as well as promoting tumor growth. Yet, NO derived from leukocytes plays a seminal role in their tumoricidal activity. In cancer treatment, NO also has diverse effects. Whereas in vitro, NO can enhance the cytotoxic efficacy of some chemotherapeutic agents as well as radiation, NO donors can provide whole body protection against these same agents. This manuscript will discuss some mechanisms involved with NO and cancer treatment modalities and the potential application of these findings to cancer therapy.",

author = "Wink, {D. A.} and Y. Vodovotz and Cook, {J. A.} and Krishna, {M. C.} and S. Kim and D. Coffin and W. DeGraff and Deluca, {A. M.} and J. Liebmann and Mitchell, {J. B.}",

year = "1998",

month = jul,

language = "English",

volume = "63",

pages = "948--957",

journal = "Biokhimiya",

issn = "0320-9725",

number = "7",

}

TY - JOUR

T1 - Role of nitric oxide chemistry in cancer treatment

AU - Wink, D. A.

AU - Vodovotz, Y.

AU - Cook, J. A.

AU - Krishna, M. C.

AU - Kim, S.

AU - Coffin, D.

AU - DeGraff, W.

AU - Deluca, A. M.

AU - Liebmann, J.

AU - Mitchell, J. B.

PY - 1998/7

Y1 - 1998/7

N2 - Over the last decade the role of nitric oxide (NO) in various disease states has become apparent. In cancer, NO plays a variety of roles which are at times contradictory. On one hand, NO is involved in different etiological mechanisms as well as promoting tumor growth. Yet, NO derived from leukocytes plays a seminal role in their tumoricidal activity. In cancer treatment, NO also has diverse effects. Whereas in vitro, NO can enhance the cytotoxic efficacy of some chemotherapeutic agents as well as radiation, NO donors can provide whole body protection against these same agents. This manuscript will discuss some mechanisms involved with NO and cancer treatment modalities and the potential application of these findings to cancer therapy.

AB - Over the last decade the role of nitric oxide (NO) in various disease states has become apparent. In cancer, NO plays a variety of roles which are at times contradictory. On one hand, NO is involved in different etiological mechanisms as well as promoting tumor growth. Yet, NO derived from leukocytes plays a seminal role in their tumoricidal activity. In cancer treatment, NO also has diverse effects. Whereas in vitro, NO can enhance the cytotoxic efficacy of some chemotherapeutic agents as well as radiation, NO donors can provide whole body protection against these same agents. This manuscript will discuss some mechanisms involved with NO and cancer treatment modalities and the potential application of these findings to cancer therapy.

UR - http://www.scopus.com/inward/record.url?scp=0032122572&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032122572

SN - 0320-9725

VL - 63

SP - 948

EP - 957

JO - Biokhimiya

JF - Biokhimiya

IS - 7

ER -

Role of nitric oxide chemistry in cancer treatment

Abstract

Fingerprint

Cite this