TY - JOUR
T1 - Role of self-carriers in the immune response and tolerance
T2 - I. B-cell unresponsiveness and cytotoxic T-cell immunity induced by haptenated syngeneic lymphoid cells*
AU - Scott, David W.
AU - Long, Carol Ann
PY - 1976/11/2
Y1 - 1976/11/2
N2 - Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells, but go on to generate cytotoxic T cells directed at hapten-modified H-2, These results suggest that hapten-modified spleen cells may differentially induce B-ceU tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.
AB - Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells, but go on to generate cytotoxic T cells directed at hapten-modified H-2, These results suggest that hapten-modified spleen cells may differentially induce B-ceU tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0017110334&partnerID=8YFLogxK
U2 - 10.1084/jem.144.5.1369
DO - 10.1084/jem.144.5.1369
M3 - Article
C2 - 1086885
AN - SCOPUS:0017110334
SN - 0022-1007
VL - 144
SP - 1369
EP - 1374
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 5
ER -