Role of self-carriers in the immune response and tolerance: I. B-cell unresponsiveness and cytotoxic T-cell immunity induced by haptenated syngeneic lymphoid cells*

David W. Scott; Carol Ann Long

doi:10.1084/jem.144.5.1369

Role of self-carriers in the immune response and tolerance: I. B-cell unresponsiveness and cytotoxic T-cell immunity induced by haptenated syngeneic lymphoid cells*

David W. Scott, Carol Ann Long

Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells, but go on to generate cytotoxic T cells directed at hapten-modified H-2, These results suggest that hapten-modified spleen cells may differentially induce B-ceU tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.

Original language	English
Pages (from-to)	1369-1374
Number of pages	6
Journal	Journal of Experimental Medicine
Volume	144
Issue number	5
DOIs	https://doi.org/10.1084/jem.144.5.1369
State	Published - 2 Nov 1976

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abstract = "Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells, but go on to generate cytotoxic T cells directed at hapten-modified H-2, These results suggest that hapten-modified spleen cells may differentially induce B-ceU tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.",

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Role of self-carriers in the immune response and tolerance: I. B-cell unresponsiveness and cytotoxic T-cell immunity induced by haptenated syngeneic lymphoid cells*

Abstract

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