Abstract
Previous studies indicated that T cells are required for tolerance induction by hapten-modified syngeneic spleen cells (TNP-SC) in vivo. The role of T cells in the maintenance of this unresponsive state has been examined herein: By three criteria - limiting dilution precursor analysis, removal of T cells by anti-Thy-1 + C, and direct mixing experiments - we show that T cells are required for the continued suppression of the B cell response to the T-independent antigen, TNP-POL. Suppressor cells can also be induced by TNP-teratoma cells, which lack detectable H-2 antigens. Both anti-Ly-1 + C and anti-Ly-2 + C treatment reversed suppression induced by TNP-SC. These results demonstrate that normal B cell reactivity is present in the spleens of mice rendered tolerant by haptenated self, but that Ly - 1,2,3 or Ly-1 + Ly-2,3 suppressor T cells prevent their responsiveness.
Original language | English |
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Pages (from-to) | 2447-2450 |
Number of pages | 4 |
Journal | Journal of Immunology |
Volume | 123 |
Issue number | 6 |
State | Published - 1979 |
Externally published | Yes |