Role of self carriers in the immune response and tolerance. IV. Active cell suppression in the maintenance of B cell tolerance to a 'T-independent' antigen

J. J. Jandinski, D. W. Scott

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Previous studies indicated that T cells are required for tolerance induction by hapten-modified syngeneic spleen cells (TNP-SC) in vivo. The role of T cells in the maintenance of this unresponsive state has been examined herein: By three criteria - limiting dilution precursor analysis, removal of T cells by anti-Thy-1 + C, and direct mixing experiments - we show that T cells are required for the continued suppression of the B cell response to the T-independent antigen, TNP-POL. Suppressor cells can also be induced by TNP-teratoma cells, which lack detectable H-2 antigens. Both anti-Ly-1 + C and anti-Ly-2 + C treatment reversed suppression induced by TNP-SC. These results demonstrate that normal B cell reactivity is present in the spleens of mice rendered tolerant by haptenated self, but that Ly - 1,2,3 or Ly-1 + Ly-2,3 suppressor T cells prevent their responsiveness.

Original languageEnglish
Pages (from-to)2447-2450
Number of pages4
JournalJournal of Immunology
Volume123
Issue number6
StatePublished - 1979
Externally publishedYes

Fingerprint

Dive into the research topics of 'Role of self carriers in the immune response and tolerance. IV. Active cell suppression in the maintenance of B cell tolerance to a 'T-independent' antigen'. Together they form a unique fingerprint.

Cite this