TY - JOUR
T1 - Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication
AU - Seifert, Stephanie N.
AU - Letko, Michael C.
AU - Bushmaker, Trenton
AU - Laing, Eric D.
AU - Saturday, Greg
AU - Meade-White, Kimberly
AU - Van Doremalen, Neeltje
AU - Broder, Christopher C.
AU - Munster, Vincent J.
N1 - Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2020/5/11
Y1 - 2020/5/11
N2 - Nipah virus (NiV) is a bat-borne zoonotic pathogen that can cause severe respiratory distress and encephalitis upon spillover into humans. NiV is capable of infecting a broad range of hosts including humans, pigs, ferrets, dogs, cats, hamsters, and at least 2 genera of bats. Little is known about the biology of NiV in the bat reservoir. In this study, we evaluate the potential for the Egyptian fruit bat (EFB), Rousettus aegyptiacus, to serve as a model organism for studying NiV in bats. Our data suggest that NiV does not efficiently replicate in EFBs in vivo. Furthermore, we show no seroconversion against NiV glycoprotein and a lack of viral replication in primary and immortalized EFB-derived cell lines. Our data show that despite using a conserved target for viral entry, NiV replication is limited in some bat species. We conclude that EFBs are not an appropriate organism to model NiV infection or transmission in bats.
AB - Nipah virus (NiV) is a bat-borne zoonotic pathogen that can cause severe respiratory distress and encephalitis upon spillover into humans. NiV is capable of infecting a broad range of hosts including humans, pigs, ferrets, dogs, cats, hamsters, and at least 2 genera of bats. Little is known about the biology of NiV in the bat reservoir. In this study, we evaluate the potential for the Egyptian fruit bat (EFB), Rousettus aegyptiacus, to serve as a model organism for studying NiV in bats. Our data suggest that NiV does not efficiently replicate in EFBs in vivo. Furthermore, we show no seroconversion against NiV glycoprotein and a lack of viral replication in primary and immortalized EFB-derived cell lines. Our data show that despite using a conserved target for viral entry, NiV replication is limited in some bat species. We conclude that EFBs are not an appropriate organism to model NiV infection or transmission in bats.
KW - Egyptian fruit bats
KW - Nipah virus
KW - bats
KW - experimental infection
UR - http://www.scopus.com/inward/record.url?scp=85082631943&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiz429
DO - 10.1093/infdis/jiz429
M3 - Article
C2 - 31682727
AN - SCOPUS:85082631943
SN - 0022-1899
VL - 221
SP - S407-S413
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -