Scaffolds for skeletal muscle tissue engineering

Joseph Bartolacci, Jenna Dziki, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


The ability of skeletal muscle to regenerate after acute injury is compromised in the case of disease or massive traumatic injury (i.e., volumetric muscle loss). An understanding of the mechanisms by which skeletal muscle can acutely regenerate has informed the development of tissue engineering and regenerative medicine-based approaches to treat muscle injuries traditionally considered irreparable using both cell-based and acellular approaches. This chapter discusses the use of stem cells and diverse scaffold materials, synthetic, biosynthetic, and biologic in nature, to promote functional myogenesis. The preclinical and clinical progress of each of these methods and barriers to their further utility as a clinical therapy are discussed.

Original languageEnglish
Title of host publicationHandbook of Tissue Engineering Scaffolds
Subtitle of host publicationVolume One
Number of pages14
ISBN (Electronic)9780081025635
ISBN (Print)9780081025642
StatePublished - 1 Jan 2019


  • ECM
  • Foreign body reaction
  • Macrophage phenotype
  • Regenerative medicine strategies
  • Skeletal muscle engineering
  • Tissue engineering scaffolds


Dive into the research topics of 'Scaffolds for skeletal muscle tissue engineering'. Together they form a unique fingerprint.

Cite this