Schistosoma mansoni: Sex-specific modulation of parasite growth by host immune signals

David C. Hernandez, K. C. Lim, James H. McKerrow, Stephen J. Davies*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Development of female schistosomes from infectious cercariae to mature egg-producing adults requires both male schistosomes and an intact adaptive immune system. By examining single sex infections in immunodeficient mice, we provide evidence that female schistosome development is not directly influenced by the adaptive immune system, whereas male development is. Our data are consistent with a sequential model of schistosome development, where the adaptive immune system signals development of mature males, which subsequently stimulate development of mature females. The male schistosome therefore appears to play a central role both in transducing signals from the adaptive immune system and in facilitating female development.

Original languageEnglish
Pages (from-to)59-61
Number of pages3
JournalExperimental Parasitology
Volume106
Issue number1-2
DOIs
StatePublished - Jan 2004

Keywords

  • Adaptive immunity
  • Developmental biology
  • Dioecy
  • Recombination activating gene
  • Schistosoma mansoni
  • Trematode

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