Abstract
Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches.
Original language | English |
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Pages (from-to) | 629-631 |
Number of pages | 3 |
Journal | Trends in Cancer |
Volume | 8 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2022 |
Externally published | Yes |
Keywords
- T cell exhaustion
- immunosurveillance
- immunotherapy
- innate-like cytotoxic T cells
- tumor homing