Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance

Blaire E. Barton, Cindy H. Chau, William D. Figg*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches.

Original languageEnglish
Pages (from-to)629-631
Number of pages3
JournalTrends in Cancer
Issue number8
StatePublished - Aug 2022
Externally publishedYes


  • T cell exhaustion
  • immunosurveillance
  • immunotherapy
  • innate-like cytotoxic T cells
  • tumor homing


Dive into the research topics of 'Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance'. Together they form a unique fingerprint.

Cite this