Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance

Blaire E. Barton; Cindy H. Chau; William D. Figg

doi:10.1016/j.trecan.2022.05.003

Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance

Blaire E. Barton, Cindy H. Chau, William D. Figg^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches.

Original language	English
Pages (from-to)	629-631
Number of pages	3
Journal	Trends in Cancer
Volume	8
Issue number	8
DOIs	https://doi.org/10.1016/j.trecan.2022.05.003
State	Published - Aug 2022

Keywords

T cell exhaustion
immunosurveillance
immunotherapy
innate-like cytotoxic T cells
tumor homing

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10.1016/j.trecan.2022.05.003

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title = "Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance",

abstract = "Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches.",

keywords = "T cell exhaustion, immunosurveillance, immunotherapy, innate-like cytotoxic T cells, tumor homing",

author = "Barton, {Blaire E.} and Chau, {Cindy H.} and Figg, {William D.}",

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AU - Barton, Blaire E.

AU - Chau, Cindy H.

AU - Figg, William D.

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N2 - Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches.

AB - Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells. These cells may improve the efficacy of cancer immunotherapies, especially for patients refractory or unresponsive to current approaches.

KW - T cell exhaustion

KW - immunosurveillance

KW - immunotherapy

KW - innate-like cytotoxic T cells

KW - tumor homing

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DO - 10.1016/j.trecan.2022.05.003

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JO - Trends in Cancer

JF - Trends in Cancer

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ER -

Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance

Abstract

Keywords

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