Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel

Darrell E. Singer; Rachel Schneerson; Christian T. Bautista; Mark V. Rubertone; John B. Robbins; David N. Taylor

doi:10.1016/j.vaccine.2007.11.085

Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel

Darrell E. Singer^*, Rachel Schneerson, Christian T. Bautista, Mark V. Rubertone, John B. Robbins, David N. Taylor

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83 μg/mL). Three doses elicited a GMC of 59.92 μg/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44 μg/mL and 67.9% and the sixth of 276.95 μg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.

Original language	English
Pages (from-to)	869-873
Number of pages	5
Journal	Vaccine
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.vaccine.2007.11.085
State	Published - 13 Feb 2008
Externally published	Yes

Keywords

Anthrax
Bacillus anthracis
IgG
Military
Vaccine

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10.1016/j.vaccine.2007.11.085

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title = "Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel",

abstract = "The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83 μg/mL). Three doses elicited a GMC of 59.92 μg/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44 μg/mL and 67.9% and the sixth of 276.95 μg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.",

keywords = "Anthrax, Bacillus anthracis, IgG, Military, Vaccine",

author = "Singer, {Darrell E.} and Rachel Schneerson and Bautista, {Christian T.} and Rubertone, {Mark V.} and Robbins, {John B.} and Taylor, {David N.}",

note = "Funding Information: Financial / Support: This study was approved by the Walter Reed Army Institute of Research (WRAIR Protocol # 943), and was supported in part by the Intramural Research Program of the National Institute of Child Health and Human Development (NICHD), NIH. ",

year = "2008",

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doi = "10.1016/j.vaccine.2007.11.085",

language = "English",

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AU - Singer, Darrell E.

AU - Schneerson, Rachel

AU - Bautista, Christian T.

AU - Rubertone, Mark V.

AU - Robbins, John B.

AU - Taylor, David N.

N1 - Funding Information: Financial / Support: This study was approved by the Walter Reed Army Institute of Research (WRAIR Protocol # 943), and was supported in part by the Intramural Research Program of the National Institute of Child Health and Human Development (NICHD), NIH.

PY - 2008/2/13

Y1 - 2008/2/13

N2 - The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83 μg/mL). Three doses elicited a GMC of 59.92 μg/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44 μg/mL and 67.9% and the sixth of 276.95 μg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.

AB - The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83 μg/mL). Three doses elicited a GMC of 59.92 μg/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44 μg/mL and 67.9% and the sixth of 276.95 μg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.

KW - Anthrax

KW - Bacillus anthracis

KW - IgG

KW - Military

KW - Vaccine

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SN - 0264-410X

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JF - Vaccine

IS - 7

ER -

Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel

Abstract

Keywords

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