TY - JOUR
T1 - Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women
AU - Zhang, Yawei
AU - Wise, John Piece
AU - Holford, Theodore R.
AU - Xie, Hong
AU - Boyle, Peter
AU - Zahm, Shelia Hoar
AU - Rusiecki, Jennifer
AU - Zou, Kaiyong
AU - Zhang, Bing
AU - Zhu, Yong
AU - Owens, Patricia H.
AU - Zheng, Tongzhang
N1 - Funding Information:
This study was supported by grant CA62006-05 from the National Cancer Institute.
PY - 2004/12/15
Y1 - 2004/12/15
N2 - Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. The authors report results from a case-control study evaluating the potential effect of gene-environment interaction between CYP1A1 and serum PCB levels on breast cancer risk among Caucasian women in Connecticut. The study included 374 case women with histologically confirmed breast cancer and 406 noncancerous controls with information on both serum PCB level and CYP1A1 genotype (1999-2002). Compared with women who had the homozygous wild-type CYP1A1 m2 genotype, significantly increased risks of breast cancer were found for women with the CYP1A1 m2 variant genotype (odds ratio (OR) = 2.1, 95% confidence interval (CI): 1.1, 3.9), especially postmenopausal women (OR = 2.4, 95% CI: 1.1, 5.0). Risks associated with the CYP1A1 m2 variant genotype were highest for all women (OR = 3.6, 95% CI: 1.5, 8.2) and postmenopausal women (OR = 4.3, 95% CI: 1.6, 12.0) with higher serum PCB levels (611-2,600 ng/g). The CYP1A1 ml and m4 genotypes were not associated with breast cancer risk independently or in combination with PCB exposure. In summary, the CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer and may modify the relation between PCB exposure and breast cancer risk.
AB - Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. The authors report results from a case-control study evaluating the potential effect of gene-environment interaction between CYP1A1 and serum PCB levels on breast cancer risk among Caucasian women in Connecticut. The study included 374 case women with histologically confirmed breast cancer and 406 noncancerous controls with information on both serum PCB level and CYP1A1 genotype (1999-2002). Compared with women who had the homozygous wild-type CYP1A1 m2 genotype, significantly increased risks of breast cancer were found for women with the CYP1A1 m2 variant genotype (odds ratio (OR) = 2.1, 95% confidence interval (CI): 1.1, 3.9), especially postmenopausal women (OR = 2.4, 95% CI: 1.1, 5.0). Risks associated with the CYP1A1 m2 variant genotype were highest for all women (OR = 3.6, 95% CI: 1.5, 8.2) and postmenopausal women (OR = 4.3, 95% CI: 1.6, 12.0) with higher serum PCB levels (611-2,600 ng/g). The CYP1A1 ml and m4 genotypes were not associated with breast cancer risk independently or in combination with PCB exposure. In summary, the CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer and may modify the relation between PCB exposure and breast cancer risk.
KW - Breast neoplasms
KW - Cytochrome P-450 enzyme system
KW - Genetics
KW - Polychlorinated biphenyls
KW - Polymorphism (genetics)
KW - Risk factors
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=10344256728&partnerID=8YFLogxK
U2 - 10.1093/aje/kwh346
DO - 10.1093/aje/kwh346
M3 - Article
C2 - 15583370
AN - SCOPUS:10344256728
SN - 0002-9262
VL - 160
SP - 1177
EP - 1183
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 12
ER -