Shiga Toxin (Stx) Classification, Structure, and Function

Angela R. Melton-Celsa

doi:10.1128/9781555818791.ch3

Shiga Toxin (Stx) Classification, Structure, and Function

Angela R. Melton-Celsa^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Shiga toxin (Stx) is one of the most potent biological poisons known. Stx causes fluid accumulation in rabbit ileal loops; causes renal damage in mice, rabbits, greyhounds, and baboons; and is lethal to animals upon injection. However, humans encounter Stx as a consequence of infection with Shigella dysenteriae type 1 or certain serogroups of Escherichia coli such as O157:H7. There are two immunologically distinct groups of Stxs, and this review discusses toxin classification, structure, and function and the virulence associated with Stx-producing E. coli (STEC).

Original language	English
Title of host publication	Enterohemorrhagic Escherichia coli and Other Shiga Toxin-Producing E. coli
Publisher	wiley
Pages	37-53
Number of pages	17
ISBN (Electronic)	9781683670551
ISBN (Print)	9781119714200
DOIs	https://doi.org/10.1128/9781555818791.ch3
State	Published - 1 Jan 2015
Externally published	Yes

Keywords

Cell binding
Human disease
Retrograde trafficking pathway
Shiga toxin classification structure
Target cells

Access to Document

10.1128/9781555818791.ch3

Cite this

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AB - Shiga toxin (Stx) is one of the most potent biological poisons known. Stx causes fluid accumulation in rabbit ileal loops; causes renal damage in mice, rabbits, greyhounds, and baboons; and is lethal to animals upon injection. However, humans encounter Stx as a consequence of infection with Shigella dysenteriae type 1 or certain serogroups of Escherichia coli such as O157:H7. There are two immunologically distinct groups of Stxs, and this review discusses toxin classification, structure, and function and the virulence associated with Stx-producing E. coli (STEC).

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