Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection

Nicolaos C. Tassopoulos; Maria H. Sjogren; John R. Ticehurst; Ronald E. Engle; Anastasia Roumeliotou‐Karayannis; John L. Gerin; Robert H. Purcell; George Papaevangelou

doi:10.1111/j.1600-0676.1986.tb00291.x

Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection

Nicolaos C. Tassopoulos, Maria H. Sjogren, John R. Ticehurst, Ronald E. Engle, Anastasia Roumeliotou‐Karayannis, John L. Gerin, Robert H. Purcell, George Papaevangelou^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

ABSTRACT— IgM antibody to hepatitis B core antigen (IgM anti‐HBc) may indicate an active immune response to persistent infection with hepatitis B virus (HBV). We studied 186 Greek HBsAg carriers for IgM anti‐HBc and attempted to correlate it with other HBV and hepatitis delta virus (HDV) markers. Overall, IgM anti‐HBc was detected more frequently than HBV DNA in this population (50% vs 34, p<0.001); this was also true for the 149 of the 186 HBsAg carriers with antibody to hepatitis B e antigen (anti‐HBe) (48% vs 22%, p<0.001). The opposite was found in the carriers positive for hepatitis B e antigen (HBeAg): HBV DNA was observed in 93% and IgM anti‐HBc in 64% of the cases (p<0.05). The detection of these markers was independent of sex. Serum alanine aminotransferase (ALT) levels were significantly more elevated in patients with positive tests for IgM anti‐HBc and HBV DNA than in patients positive only for HBV DNA (p<0.001) irrespective of their HBeAg or anti‐HBe status. Moreover, the detection of elevated ALT was independent of the intensity of the HBV DNA hybridization signal. Antibodies to hepatitis delta antigen (HDAg) were only found in 4 (2.4%) of 167 patients tested.

Original language	English
Pages (from-to)	275-280
Number of pages	6
Journal	Liver
Volume	6
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0676.1986.tb00291.x
State	Published - Oct 1986
Externally published	Yes

Keywords

HBV DNA
HBsAg
IgM anti‐HBc
chronic hepatitis B

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10.1111/j.1600-0676.1986.tb00291.x

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title = "Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection",

abstract = "ABSTRACT— IgM antibody to hepatitis B core antigen (IgM anti‐HBc) may indicate an active immune response to persistent infection with hepatitis B virus (HBV). We studied 186 Greek HBsAg carriers for IgM anti‐HBc and attempted to correlate it with other HBV and hepatitis delta virus (HDV) markers. Overall, IgM anti‐HBc was detected more frequently than HBV DNA in this population (50% vs 34, p<0.001); this was also true for the 149 of the 186 HBsAg carriers with antibody to hepatitis B e antigen (anti‐HBe) (48% vs 22%, p<0.001). The opposite was found in the carriers positive for hepatitis B e antigen (HBeAg): HBV DNA was observed in 93% and IgM anti‐HBc in 64% of the cases (p<0.05). The detection of these markers was independent of sex. Serum alanine aminotransferase (ALT) levels were significantly more elevated in patients with positive tests for IgM anti‐HBc and HBV DNA than in patients positive only for HBV DNA (p<0.001) irrespective of their HBeAg or anti‐HBe status. Moreover, the detection of elevated ALT was independent of the intensity of the HBV DNA hybridization signal. Antibodies to hepatitis delta antigen (HDAg) were only found in 4 (2.4%) of 167 patients tested.",

keywords = "HBV DNA, HBsAg, IgM anti‐HBc, chronic hepatitis B",

author = "Tassopoulos, {Nicolaos C.} and Sjogren, {Maria H.} and Ticehurst, {John R.} and Engle, {Ronald E.} and Anastasia Roumeliotou‐Karayannis and Gerin, {John L.} and Purcell, {Robert H.} and George Papaevangelou",

year = "1986",

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doi = "10.1111/j.1600-0676.1986.tb00291.x",

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T1 - Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection

AU - Tassopoulos, Nicolaos C.

AU - Sjogren, Maria H.

AU - Ticehurst, John R.

AU - Engle, Ronald E.

AU - Roumeliotou‐Karayannis, Anastasia

AU - Gerin, John L.

AU - Purcell, Robert H.

AU - Papaevangelou, George

PY - 1986/10

Y1 - 1986/10

N2 - ABSTRACT— IgM antibody to hepatitis B core antigen (IgM anti‐HBc) may indicate an active immune response to persistent infection with hepatitis B virus (HBV). We studied 186 Greek HBsAg carriers for IgM anti‐HBc and attempted to correlate it with other HBV and hepatitis delta virus (HDV) markers. Overall, IgM anti‐HBc was detected more frequently than HBV DNA in this population (50% vs 34, p<0.001); this was also true for the 149 of the 186 HBsAg carriers with antibody to hepatitis B e antigen (anti‐HBe) (48% vs 22%, p<0.001). The opposite was found in the carriers positive for hepatitis B e antigen (HBeAg): HBV DNA was observed in 93% and IgM anti‐HBc in 64% of the cases (p<0.05). The detection of these markers was independent of sex. Serum alanine aminotransferase (ALT) levels were significantly more elevated in patients with positive tests for IgM anti‐HBc and HBV DNA than in patients positive only for HBV DNA (p<0.001) irrespective of their HBeAg or anti‐HBe status. Moreover, the detection of elevated ALT was independent of the intensity of the HBV DNA hybridization signal. Antibodies to hepatitis delta antigen (HDAg) were only found in 4 (2.4%) of 167 patients tested.

AB - ABSTRACT— IgM antibody to hepatitis B core antigen (IgM anti‐HBc) may indicate an active immune response to persistent infection with hepatitis B virus (HBV). We studied 186 Greek HBsAg carriers for IgM anti‐HBc and attempted to correlate it with other HBV and hepatitis delta virus (HDV) markers. Overall, IgM anti‐HBc was detected more frequently than HBV DNA in this population (50% vs 34, p<0.001); this was also true for the 149 of the 186 HBsAg carriers with antibody to hepatitis B e antigen (anti‐HBe) (48% vs 22%, p<0.001). The opposite was found in the carriers positive for hepatitis B e antigen (HBeAg): HBV DNA was observed in 93% and IgM anti‐HBc in 64% of the cases (p<0.05). The detection of these markers was independent of sex. Serum alanine aminotransferase (ALT) levels were significantly more elevated in patients with positive tests for IgM anti‐HBc and HBV DNA than in patients positive only for HBV DNA (p<0.001) irrespective of their HBeAg or anti‐HBe status. Moreover, the detection of elevated ALT was independent of the intensity of the HBV DNA hybridization signal. Antibodies to hepatitis delta antigen (HDAg) were only found in 4 (2.4%) of 167 patients tested.

KW - HBV DNA

KW - HBsAg

KW - IgM anti‐HBc

KW - chronic hepatitis B

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JO - Liver

JF - Liver

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ER -

Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection

Abstract

Keywords

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