Similarity-driven multi-view embeddings from high-dimensional biomedical data

Brian B. Avants*, Nicholas J. Tustison, James R. Stone

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Diverse, high-dimensional modalities collected in large cohorts present new opportunities for the formulation and testing of integrative scientific hypotheses. Similarity-driven multi-view linear reconstruction (SiMLR) is an algorithm that exploits inter-modality relationships to transform large scientific datasets into smaller, more well-powered and interpretable low-dimensional spaces. SiMLR contributes an objective function to identify joint signal regularization based on sparse matrices representing prior within-modality relationships and an implementation that permits application to joint reduction of large data matrices. We demonstrate that SiMLR outperlforms closely related methods on supervised learning problems in simulation data, a multi-omics cancer survival prediction dataset and multiple modality neuroimaging datasets. Taken together, this collection of results shows that SiMLR may be applied to joint signal estimation from disparate modalities and may yield practically useful results in a variety of application domains.

Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalNature Computational Science
Volume1
Issue number2
DOIs
StatePublished - Feb 2021
Externally publishedYes

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