Simultaneous optical and electrical in vivo analysis of the enteric nervous system

Nikolai Rakhilin; Bradley Barth; Jiahn Choi; Nini L. Muñoz; Subhash Kulkarni; Jason S. Jones; David M. Small; Yu Ting Cheng; Yingqiu Cao; Colleen Lavinka; Edwin Kan; Xinzhong Dong; Michael Spencer; Pankaj Pasricha; Nozomi Nishimura; Xiling Shen

doi:10.1038/ncomms11800

Simultaneous optical and electrical in vivo analysis of the enteric nervous system

Nikolai Rakhilin, Bradley Barth, Jiahn Choi, Nini L. Muñoz, Subhash Kulkarni, Jason S. Jones, David M. Small, Yu Ting Cheng, Yingqiu Cao, Colleen Lavinka, Edwin Kan, Xinzhong Dong, Michael Spencer, Pankaj Pasricha, Nozomi Nishimura, Xiling Shen^*

^*Corresponding author for this work

Radiology and Bioengineering

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.

Original language	English
Article number	11800
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms11800
State	Published - 7 Jun 2016

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10.1038/ncomms11800

Cite this

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abstract = "The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.",

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AU - Rakhilin, Nikolai

AU - Barth, Bradley

AU - Choi, Jiahn

AU - Muñoz, Nini L.

AU - Kulkarni, Subhash

AU - Jones, Jason S.

AU - Small, David M.

AU - Cheng, Yu Ting

AU - Cao, Yingqiu

AU - Lavinka, Colleen

AU - Kan, Edwin

AU - Dong, Xinzhong

AU - Spencer, Michael

AU - Pasricha, Pankaj

AU - Nishimura, Nozomi

AU - Shen, Xiling

PY - 2016/6/7

Y1 - 2016/6/7

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