TY - JOUR
T1 - Simultaneous pancreas - kidney transplantation
T2 - Recent experience at the University of Wisconsin
AU - Rayhill, S. C.
AU - Heimes, M.
AU - Kirk, A. D.
AU - Sollinger, H. W.
PY - 1996
Y1 - 1996
N2 - After a decade of rapid development, simultaneous pancreas - kidney (SPK) transplantation has become routine at the University of Wisconsin (UW). Since developing the concept of direct drainage of pancreas allograft exocrine secretions into the urinary bladder at UW in 1982, we performed 381 SPK transplantations in this technique. Patient and graft survival following SPK transplantation has increased significantly from our early experience to the recent time. The one- and five-year patient survival rates for the entire series of 381 SPK transplantations were 96% and 88%, respectively. The actuarial one- and five-year kidney allograft survival rates in these patients were 87% and 78%. The pancreas allograft survival rates were similar at 86% and 74%. Several changes are responsible for our current high level of success: UW preservation solution, improved surgical technique, advances in immunosuppression, and expeditious diagnosis and treatment of complications.
AB - After a decade of rapid development, simultaneous pancreas - kidney (SPK) transplantation has become routine at the University of Wisconsin (UW). Since developing the concept of direct drainage of pancreas allograft exocrine secretions into the urinary bladder at UW in 1982, we performed 381 SPK transplantations in this technique. Patient and graft survival following SPK transplantation has increased significantly from our early experience to the recent time. The one- and five-year patient survival rates for the entire series of 381 SPK transplantations were 96% and 88%, respectively. The actuarial one- and five-year kidney allograft survival rates in these patients were 87% and 78%. The pancreas allograft survival rates were similar at 86% and 74%. Several changes are responsible for our current high level of success: UW preservation solution, improved surgical technique, advances in immunosuppression, and expeditious diagnosis and treatment of complications.
KW - Complications
KW - Immunosuppression
KW - Pancreas - kidney transplantation
KW - Surgical technique
KW - Urinary drainage
UR - http://www.scopus.com/inward/record.url?scp=0029849772&partnerID=8YFLogxK
U2 - 10.1055/s-0029-1211467
DO - 10.1055/s-0029-1211467
M3 - Review article
C2 - 8957269
AN - SCOPUS:0029849772
SN - 0947-7349
VL - 104
SP - 353
EP - 359
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
IS - 5
ER -