Six patterns of drug-drug interactions

Scott C Armstrong; Kelly L Cozza; Neil B Sandson

doi:10.1176/appi.psy.44.3.255

Six patterns of drug-drug interactions

Scott C Armstrong, Kelly L Cozza, Neil B Sandson

Psychiatry

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The literature on pharmacokinetic drug-drug interactions usually focuses on various interactions relating to the cytochrome p450 system, phase II glucuronidation, and P-glycoprotein function. However, there has been relatively little examination of how the modes or patterns that govern these interactions can be systematically characterized to better anticipate drug-drug interactions in clinical practice. This article details a schema of six core patterns of pharmacokinetic drug-drug interaction relating to processes of induction and inhibition and the action of substrates. Case examples illustrating each pattern are provided.

Original language	English
Pages (from-to)	255-8
Number of pages	4
Journal	Psychosomatics
Volume	44
Issue number	3
DOIs	https://doi.org/10.1176/appi.psy.44.3.255
State	Published - 2003

Keywords

ATP Binding Cassette Transporter, Subfamily B, Member 1/physiology
Biotransformation
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System/physiology
Drug Interactions
Drug Therapy, Combination
Enzyme Induction/drug effects
Humans
Psychotropic Drugs/adverse effects
Substrate Specificity

Access to Document

10.1176/appi.psy.44.3.255

Cite this

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KW - Cytochrome P-450 Enzyme Inhibitors

KW - Cytochrome P-450 Enzyme System/physiology

KW - Drug Interactions

KW - Drug Therapy, Combination

KW - Enzyme Induction/drug effects

KW - Humans

KW - Psychotropic Drugs/adverse effects

KW - Substrate Specificity

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