Skeletal metastases in 301 breast cancer patients:. Patient survival and complications after surgery

Rüdiger J. Weiss; Elias Tullberg; Jonathan A. Forsberg; Henrik C. Bauer; Rikard Wedin

doi:10.1016/j.breast.2014.02.012

Skeletal metastases in 301 breast cancer patients:. Patient survival and complications after surgery

Rüdiger J. Weiss^*, Elias Tullberg, Jonathan A. Forsberg, Henrik C. Bauer, Rikard Wedin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The aim was to identify prognostic variables associated with survival in 301 breast cancer patients after surgical treatment of skeletal metastases. The study period was 1986-2012. The median age at surgery was 61 (interquartile-range [IQR] 52-70) years. The cumulative 1-, 2-, and 5-year survival after surgery was 45% (95% CI 39-51), 27% (22-32), and 8% (5-12), respectively. The median follow-up time was 1 (IQR 0.2-2) year. Age over 60 years (Hazard ratio [HR] 1.9) and hemoglobin levels <110 g/L (HR 2) increased the risk of death after surgery. Patients with impending fractures (HR 0.4) had a lower death rate. The overall neurological function in patients with spinal metastases improved after surgery (p < 0.001). The complication rate was 25%, including 14% re-operations. Survival data and analysis of complications of this large cohort of surgically treated breast cancer patients help to set appropriate expectations for the patients, families, and medical staff.

Original language	English
Pages (from-to)	286-290
Number of pages	5
Journal	Breast
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.breast.2014.02.012
State	Published - Jun 2014
Externally published	Yes

Keywords

Breast cancer
Complication
Outcome
Re-operation
Skeletal metastases
Surgery

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title = "Skeletal metastases in 301 breast cancer patients:. Patient survival and complications after surgery",

abstract = "The aim was to identify prognostic variables associated with survival in 301 breast cancer patients after surgical treatment of skeletal metastases. The study period was 1986-2012. The median age at surgery was 61 (interquartile-range [IQR] 52-70) years. The cumulative 1-, 2-, and 5-year survival after surgery was 45% (95% CI 39-51), 27% (22-32), and 8% (5-12), respectively. The median follow-up time was 1 (IQR 0.2-2) year. Age over 60 years (Hazard ratio [HR] 1.9) and hemoglobin levels <110 g/L (HR 2) increased the risk of death after surgery. Patients with impending fractures (HR 0.4) had a lower death rate. The overall neurological function in patients with spinal metastases improved after surgery (p < 0.001). The complication rate was 25%, including 14% re-operations. Survival data and analysis of complications of this large cohort of surgically treated breast cancer patients help to set appropriate expectations for the patients, families, and medical staff.",

keywords = "Breast cancer, Complication, Outcome, Re-operation, Skeletal metastases, Surgery",

author = "Weiss, {R{\"u}diger J.} and Elias Tullberg and Forsberg, {Jonathan A.} and Bauer, {Henrik C.} and Rikard Wedin",

year = "2014",

month = jun,

doi = "10.1016/j.breast.2014.02.012",

language = "English",

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AU - Weiss, Rüdiger J.

AU - Tullberg, Elias

AU - Forsberg, Jonathan A.

AU - Bauer, Henrik C.

AU - Wedin, Rikard

PY - 2014/6

Y1 - 2014/6

N2 - The aim was to identify prognostic variables associated with survival in 301 breast cancer patients after surgical treatment of skeletal metastases. The study period was 1986-2012. The median age at surgery was 61 (interquartile-range [IQR] 52-70) years. The cumulative 1-, 2-, and 5-year survival after surgery was 45% (95% CI 39-51), 27% (22-32), and 8% (5-12), respectively. The median follow-up time was 1 (IQR 0.2-2) year. Age over 60 years (Hazard ratio [HR] 1.9) and hemoglobin levels <110 g/L (HR 2) increased the risk of death after surgery. Patients with impending fractures (HR 0.4) had a lower death rate. The overall neurological function in patients with spinal metastases improved after surgery (p < 0.001). The complication rate was 25%, including 14% re-operations. Survival data and analysis of complications of this large cohort of surgically treated breast cancer patients help to set appropriate expectations for the patients, families, and medical staff.

AB - The aim was to identify prognostic variables associated with survival in 301 breast cancer patients after surgical treatment of skeletal metastases. The study period was 1986-2012. The median age at surgery was 61 (interquartile-range [IQR] 52-70) years. The cumulative 1-, 2-, and 5-year survival after surgery was 45% (95% CI 39-51), 27% (22-32), and 8% (5-12), respectively. The median follow-up time was 1 (IQR 0.2-2) year. Age over 60 years (Hazard ratio [HR] 1.9) and hemoglobin levels <110 g/L (HR 2) increased the risk of death after surgery. Patients with impending fractures (HR 0.4) had a lower death rate. The overall neurological function in patients with spinal metastases improved after surgery (p < 0.001). The complication rate was 25%, including 14% re-operations. Survival data and analysis of complications of this large cohort of surgically treated breast cancer patients help to set appropriate expectations for the patients, families, and medical staff.

KW - Breast cancer

KW - Complication

KW - Outcome

KW - Re-operation

KW - Skeletal metastases

KW - Surgery

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JO - Breast

JF - Breast

IS - 3

ER -

Skeletal metastases in 301 breast cancer patients:. Patient survival and complications after surgery

Abstract

Keywords

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