Sleep derangements in central nervous system infections

Gilbert Seda, Teofilo Lee-Chiong, John Harrington*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Significant disturbances of sleep architecture and sleep quality can develop in several central nervous system (CNS) infections. The changes in sleep differ among the various infectious agents. Some cases of narcolepsy are believed to be related to postinfectious autoimmune processes by the interaction between innate genetic susceptibility and exposure to specific pathogens. Infection with HIV can give rise to insomnia, daytime fatigue, and depression. Infections of the CNS can affect the brainstem respiratory centers resulting in abnormal breathing patterns during sleep. Parasomnias and alterations in circadian rhythms have been described in some CNS infections.

Original languageEnglish
Pages (from-to)703-711
Number of pages9
JournalSleep Medicine Clinics
Issue number4
StatePublished - Dec 2012
Externally publishedYes


  • Central nervous system infections
  • HIV
  • Insomnia
  • Narcolepsy
  • Parasomnias
  • Sleeping sickness


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