Smallpox vaccination and ischemic coronary events in healthy adults

Robert E. Eckart*, Eric A. Shry, J. Edwin Atwood, John F. Brundage, Jenny C. Lay, Thomas F. Bateson, John D. Grabenstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.

Original languageEnglish
Pages (from-to)8359-8364
Number of pages6
Issue number50
StatePublished - 5 Dec 2007
Externally publishedYes


  • Acute coronary syndrome
  • Angina
  • Coronary artery disease
  • Myocardial infarction
  • Smallpox vaccination
  • Vaccinia virus


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