Smallpox vaccination and ischemic coronary events in healthy adults

Robert E. Eckart; Eric A. Shry; J. Edwin Atwood; John F. Brundage; Jenny C. Lay; Thomas F. Bateson; John D. Grabenstein

doi:10.1016/j.vaccine.2007.09.064

Smallpox vaccination and ischemic coronary events in healthy adults

Robert E. Eckart^*, Eric A. Shry, J. Edwin Atwood, John F. Brundage, Jenny C. Lay, Thomas F. Bateson, John D. Grabenstein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.

Original language	English
Pages (from-to)	8359-8364
Number of pages	6
Journal	Vaccine
Volume	25
Issue number	50
DOIs	https://doi.org/10.1016/j.vaccine.2007.09.064
State	Published - 5 Dec 2007
Externally published	Yes

Keywords

Acute coronary syndrome
Angina
Coronary artery disease
Myocardial infarction
Smallpox vaccination
Vaccinia virus

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10.1016/j.vaccine.2007.09.064

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title = "Smallpox vaccination and ischemic coronary events in healthy adults",

abstract = "Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.",

keywords = "Acute coronary syndrome, Angina, Coronary artery disease, Myocardial infarction, Smallpox vaccination, Vaccinia virus",

author = "Eckart, {Robert E.} and Shry, {Eric A.} and Atwood, {J. Edwin} and Brundage, {John F.} and Lay, {Jenny C.} and Bateson, {Thomas F.} and Grabenstein, {John D.}",

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doi = "10.1016/j.vaccine.2007.09.064",

language = "English",

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TY - JOUR

T1 - Smallpox vaccination and ischemic coronary events in healthy adults

AU - Eckart, Robert E.

AU - Shry, Eric A.

AU - Atwood, J. Edwin

AU - Brundage, John F.

AU - Lay, Jenny C.

AU - Bateson, Thomas F.

AU - Grabenstein, John D.

PY - 2007/12/5

Y1 - 2007/12/5

N2 - Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.

AB - Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.

KW - Acute coronary syndrome

KW - Angina

KW - Coronary artery disease

KW - Myocardial infarction

KW - Smallpox vaccination

KW - Vaccinia virus

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DO - 10.1016/j.vaccine.2007.09.064

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SN - 0264-410X

VL - 25

SP - 8359

EP - 8364

JO - Vaccine

JF - Vaccine

IS - 50

ER -

Smallpox vaccination and ischemic coronary events in healthy adults

Abstract

Keywords

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