Somatic activation of thalamic neurons transplanted into lesioned somatosensory thalamus

Sharon L. Juliano; Isabelle Dusart; Marc Peschanski

doi:10.1016/0006-8993(89)91516-3

Somatic activation of thalamic neurons transplanted into lesioned somatosensory thalamus

Sharon L. Juliano^*, Isabelle Dusart, Marc Peschanski

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Homotypic fetal neurons were transplanted into previously lesioned ventrobasal complex of rats. After 1-3 months of survival the animals received injections of 2-deoxy-[¹⁴C]glucose to reveal metabolic activity of the transplanted cells in response to somatic stimuli. These experiments indicated that stimulus-evoked activity in the transplants of animals receiving a somatic stimulus was significantly greater than in the transplants of animals that were not stimulated. Control studies using cell counts, cytochrome oxidase and acetylcholinesterase histochemistry established that the differences in activity values were not due to the number of surviving cells or the metabolic health of the individual grafts.

Original language	English
Pages (from-to)	356-360
Number of pages	5
Journal	Brain Research
Volume	478
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(89)91516-3
State	Published - 30 Jan 1989

Keywords

2-Deoxyglucose
Acetylcholinesterase
Cytochrome oxidase
Fetal neuron
Homotypic grafting
Metabolic activity
Ventrobasal complex

Access to Document

10.1016/0006-8993(89)91516-3

Cite this

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title = "Somatic activation of thalamic neurons transplanted into lesioned somatosensory thalamus",

abstract = "Homotypic fetal neurons were transplanted into previously lesioned ventrobasal complex of rats. After 1-3 months of survival the animals received injections of 2-deoxy-[14C]glucose to reveal metabolic activity of the transplanted cells in response to somatic stimuli. These experiments indicated that stimulus-evoked activity in the transplants of animals receiving a somatic stimulus was significantly greater than in the transplants of animals that were not stimulated. Control studies using cell counts, cytochrome oxidase and acetylcholinesterase histochemistry established that the differences in activity values were not due to the number of surviving cells or the metabolic health of the individual grafts.",

keywords = "2-Deoxyglucose, Acetylcholinesterase, Cytochrome oxidase, Fetal neuron, Homotypic grafting, Metabolic activity, Ventrobasal complex",

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T1 - Somatic activation of thalamic neurons transplanted into lesioned somatosensory thalamus

AU - Juliano, Sharon L.

AU - Dusart, Isabelle

AU - Peschanski, Marc

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Y1 - 1989/1/30

N2 - Homotypic fetal neurons were transplanted into previously lesioned ventrobasal complex of rats. After 1-3 months of survival the animals received injections of 2-deoxy-[14C]glucose to reveal metabolic activity of the transplanted cells in response to somatic stimuli. These experiments indicated that stimulus-evoked activity in the transplants of animals receiving a somatic stimulus was significantly greater than in the transplants of animals that were not stimulated. Control studies using cell counts, cytochrome oxidase and acetylcholinesterase histochemistry established that the differences in activity values were not due to the number of surviving cells or the metabolic health of the individual grafts.

AB - Homotypic fetal neurons were transplanted into previously lesioned ventrobasal complex of rats. After 1-3 months of survival the animals received injections of 2-deoxy-[14C]glucose to reveal metabolic activity of the transplanted cells in response to somatic stimuli. These experiments indicated that stimulus-evoked activity in the transplants of animals receiving a somatic stimulus was significantly greater than in the transplants of animals that were not stimulated. Control studies using cell counts, cytochrome oxidase and acetylcholinesterase histochemistry established that the differences in activity values were not due to the number of surviving cells or the metabolic health of the individual grafts.

KW - 2-Deoxyglucose

KW - Acetylcholinesterase

KW - Cytochrome oxidase

KW - Fetal neuron

KW - Homotypic grafting

KW - Metabolic activity

KW - Ventrobasal complex

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