Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults

Monique Bouvier; Wei Ju Chen; John C. Arnold; Mary P. Fairchok; Patrick J. Danaher; Tahaniyat Lalani; Leslie Malone; Deepika Mor; Michelande Ridoré; Timothy H. Burgess; Eugene V. Millar

doi:10.1111/irv.12538

Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults

Monique Bouvier, Wei Ju Chen, John C. Arnold, Mary P. Fairchok, Patrick J. Danaher, Tahaniyat Lalani, Leslie Malone, Deepika Mor, Michelande Ridoré, Timothy H. Burgess, Eugene V. Millar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.

Original language	English
Pages (from-to)	299-303
Number of pages	5
Journal	Influenza and other Respiratory Viruses
Volume	12
Issue number	2
DOIs	https://doi.org/10.1111/irv.12538
State	Published - Mar 2018
Externally published	Yes

Keywords

clinical characteristics
coronavirus
influenza-like illness

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10.1111/irv.12538

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Bouvier, M., Chen, W. J., Arnold, J. C., Fairchok, M. P., Danaher, P. J., Lalani, T., Malone, L., Mor, D., Ridoré, M., Burgess, T. H., & Millar, E. V. (2018). Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults. Influenza and other Respiratory Viruses, 12(2), 299-303. https://doi.org/10.1111/irv.12538

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title = "Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults",

abstract = "Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.",

keywords = "clinical characteristics, coronavirus, influenza-like illness",

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note = "Publisher Copyright: {\textcopyright} 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.",

year = "2018",

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doi = "10.1111/irv.12538",

language = "English",

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AU - Bouvier, Monique

AU - Chen, Wei Ju

AU - Arnold, John C.

AU - Fairchok, Mary P.

AU - Danaher, Patrick J.

AU - Lalani, Tahaniyat

AU - Malone, Leslie

AU - Mor, Deepika

AU - Ridoré, Michelande

AU - Burgess, Timothy H.

AU - Millar, Eugene V.

PY - 2018/3

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N2 - Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.

AB - Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.

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Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults

Abstract

Keywords

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