Abstract
Transforming growth factor β1 null mice (TGF-β1(-/-)) suffer from multifocal inflammation and die by 3-4 wk of age. In these mice, levels of nitric oxide (NO) reaction products in serum are elevated approximately fourfold over levels m controls, peaking at 15-17 d of life. Short-term treatment of TGF-β1(-/-) mice with N(G)-monomethyl-L-arginine suppressed this elevated production of NO. Expression of inducible NO synthase (iNOS) mRNA and protein is increased in the kidney and heart of TGF-β1(-/-) mice. These findings demonstrate that TGF-β1 negatively regulates iNOS expression in vivo, as had been inferred from mechanistic studies on the control of iNOS expression by TGF-β1 in vitro.
Original language | English |
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Pages (from-to) | 2337-2342 |
Number of pages | 6 |
Journal | Journal of Experimental Medicine |
Volume | 183 |
Issue number | 5 |
DOIs | |
State | Published - 1 May 1996 |
Externally published | Yes |