Stimulation of IL-2 production and CD2R expression by splenopentin analogs

S. Biswas; V. K. Singh; A. Rastogi; R. Sharan; W. Haq; K. B. Mathurand; S. S. Agarwal

doi:10.1016/S0192-0561(97)00032-5

Stimulation of IL-2 production and CD2R expression by splenopentin analogs

S. Biswas, V. K. Singh^*, A. Rastogi, R. Sharan, W. Haq, K. B. Mathurand, S. S. Agarwal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin. Its synthetic analogs: Lys-Lys-Glu-Val-Tyr (1) and D-Lys-Lys-Glu-Val-Tyr (2) have been evaluated for active T-cell rosette (CD2R), total T-cell rosette (CD2), interleukin-2 (IL-2) stimulation and effect on antibody production. SP-5 as well as both the analogs stimulated CD2R. Analogs (1) and (2) were also found to stimulate IL-2 production. These observations suggest that in vitro human NK cell augmentation with analogs (1) and (2) reported earlier may be due to enhanced IL-2 production.

Original language	English
Pages (from-to)	341-345
Number of pages	5
Journal	International Journal of Immunopharmacology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/S0192-0561(97)00032-5
State	Published - Jun 1997

Keywords

CD2R
Immunomodulators
Interleukin-2
Splenopentin

Access to Document

10.1016/S0192-0561(97)00032-5

Cite this

@article{04a37988e32145f290ae59be94093f9b,

title = "Stimulation of IL-2 production and CD2R expression by splenopentin analogs",

abstract = "Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin. Its synthetic analogs: Lys-Lys-Glu-Val-Tyr (1) and D-Lys-Lys-Glu-Val-Tyr (2) have been evaluated for active T-cell rosette (CD2R), total T-cell rosette (CD2), interleukin-2 (IL-2) stimulation and effect on antibody production. SP-5 as well as both the analogs stimulated CD2R. Analogs (1) and (2) were also found to stimulate IL-2 production. These observations suggest that in vitro human NK cell augmentation with analogs (1) and (2) reported earlier may be due to enhanced IL-2 production.",

keywords = "CD2R, Immunomodulators, Interleukin-2, Splenopentin",

author = "S. Biswas and Singh, {V. K.} and A. Rastogi and R. Sharan and W. Haq and Mathurand, {K. B.} and Agarwal, {S. S.}",

year = "1997",

month = jun,

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volume = "19",

pages = "341--345",

journal = "International Journal of Immunopharmacology",

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publisher = "Elsevier B.V.",

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T1 - Stimulation of IL-2 production and CD2R expression by splenopentin analogs

AU - Biswas, S.

AU - Singh, V. K.

AU - Rastogi, A.

AU - Sharan, R.

AU - Haq, W.

AU - Mathurand, K. B.

AU - Agarwal, S. S.

PY - 1997/6

Y1 - 1997/6

N2 - Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin. Its synthetic analogs: Lys-Lys-Glu-Val-Tyr (1) and D-Lys-Lys-Glu-Val-Tyr (2) have been evaluated for active T-cell rosette (CD2R), total T-cell rosette (CD2), interleukin-2 (IL-2) stimulation and effect on antibody production. SP-5 as well as both the analogs stimulated CD2R. Analogs (1) and (2) were also found to stimulate IL-2 production. These observations suggest that in vitro human NK cell augmentation with analogs (1) and (2) reported earlier may be due to enhanced IL-2 production.

AB - Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin. Its synthetic analogs: Lys-Lys-Glu-Val-Tyr (1) and D-Lys-Lys-Glu-Val-Tyr (2) have been evaluated for active T-cell rosette (CD2R), total T-cell rosette (CD2), interleukin-2 (IL-2) stimulation and effect on antibody production. SP-5 as well as both the analogs stimulated CD2R. Analogs (1) and (2) were also found to stimulate IL-2 production. These observations suggest that in vitro human NK cell augmentation with analogs (1) and (2) reported earlier may be due to enhanced IL-2 production.

KW - CD2R

KW - Immunomodulators

KW - Interleukin-2

KW - Splenopentin

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