Strategies for functional bioscaffold-based skeletal muscle reconstruction

Brian M. Sicari, Jenna L. Dziki, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

13 Scopus citations


Tissue engineering and regenerative medicine-based strategies for the reconstruction of functional skeletal muscle tissue have included cellular and acellular approaches. The use of acellular biologic scaffold material as a treatment for volumetric muscle loss (VML) in five patients has recently been reported with a generally favorable outcome. Further studies are necessary for a better understanding of the mechanism(s) behind acellular bioscaffold-mediated skeletal muscle repair, and for combination cell-based/bioscaffold based approaches. The present overview highlights the current thinking on bioscaffold-based remodeling including the associated mechanisms and the future of scaffold-based skeletal muscle reconstruction.

Original languageEnglish
Article number256
JournalAnnals of Translational Medicine
Issue number17
StatePublished - Oct 2015
Externally publishedYes


  • Bioscaffolds
  • Extracellular matrix (ECM)
  • Regenerative medicine
  • Skeletal muscle reconstruction
  • Tissue engineering
  • Volumetric muscle loss (VML)


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