TY - JOUR
T1 - Structural neuroimaging in mild traumatic brain injury
T2 - A chronic effects of neurotrauma consortium study
AU - Bigler, Erin D.
AU - Abildskov, Tracy J.
AU - Eggleston, Barry
AU - Taylor, Brian A.
AU - Tate, David F.
AU - Petrie, Jo Ann
AU - Newsome, Mary R.
AU - Scheibel, Randall S.
AU - Levin, Harvey
AU - Walker, William C.
AU - Goodrich-Hunsaker, Naomi
AU - Tustison, Nicholas J.
AU - Stone, James R.
AU - Mayer, Andrew R.
AU - Duncan, Timothy D.
AU - York, Gerry E.
AU - Wilde, Elisabeth A.
N1 - Publisher Copyright:
© 2019 John Wiley & Sons, Ltd.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Objectives: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies—Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. Methods: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. Results: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. Conclusions/Discussion: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.
AB - Objectives: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies—Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. Methods: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. Results: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. Conclusions/Discussion: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.
KW - automated image analysis
KW - cognitive assessment
KW - mild traumatic brain injury
KW - neuroimaging quantification
KW - veterans
UR - http://www.scopus.com/inward/record.url?scp=85066888427&partnerID=8YFLogxK
U2 - 10.1002/mpr.1781
DO - 10.1002/mpr.1781
M3 - Article
C2 - 31608535
AN - SCOPUS:85066888427
SN - 1049-8931
VL - 28
JO - International Journal of Methods in Psychiatric Research
JF - International Journal of Methods in Psychiatric Research
IS - 3
M1 - e1781
ER -