Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study

Erin D. Bigler*, Tracy J. Abildskov, Barry Eggleston, Brian A. Taylor, David F. Tate, Jo Ann Petrie, Mary R. Newsome, Randall S. Scheibel, Harvey Levin, William C. Walker, Naomi Goodrich-Hunsaker, Nicholas J. Tustison, James R. Stone, Andrew R. Mayer, Timothy D. Duncan, Gerry E. York, Elisabeth A. Wilde

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objectives: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies—Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. Methods: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. Results: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. Conclusions/Discussion: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.

Original languageEnglish
Article numbere1781
JournalInternational Journal of Methods in Psychiatric Research
Issue number3
StatePublished - 1 Sep 2019
Externally publishedYes


  • automated image analysis
  • cognitive assessment
  • mild traumatic brain injury
  • neuroimaging quantification
  • veterans


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