Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?

Ariel M. Ley; Cindy H. Chau; William D. Figg

doi:10.4161/15384047.2014.972828

Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?

Ariel M. Ley, Cindy H. Chau, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Another piece of the thalidomide puzzle is unraveled through structural studies of thalidomide and its derivatives bound to its protein target cereblon. Two recent studies published in Nature (Fischer et al.) and Nature Structural & Molecular Biology (Chamberlain et al.) have shed light on the drug's mechanisms of action and its complex biological effects.

Original language	English
Pages (from-to)	19-20
Number of pages	2
Journal	Cancer Biology and Therapy
Volume	16
Issue number	1
DOIs	https://doi.org/10.4161/15384047.2014.972828
State	Published - 2015
Externally published	Yes

Keywords

IMiDs
Thalidomide
angiogenesis
cereblon
immunomodulation
lenalidomide
pomalido- mide
teratogenesis
ubiquitin ligase

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abstract = "Another piece of the thalidomide puzzle is unraveled through structural studies of thalidomide and its derivatives bound to its protein target cereblon. Two recent studies published in Nature (Fischer et al.) and Nature Structural & Molecular Biology (Chamberlain et al.) have shed light on the drug's mechanisms of action and its complex biological effects.",

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N1 - Publisher Copyright: ©, This article not subject to United States copyright law.

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KW - ubiquitin ligase

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Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?

Abstract

Keywords

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