Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?

Ariel M. Ley, Cindy H. Chau, William D. Figg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Another piece of the thalidomide puzzle is unraveled through structural studies of thalidomide and its derivatives bound to its protein target cereblon. Two recent studies published in Nature (Fischer et al.) and Nature Structural & Molecular Biology (Chamberlain et al.) have shed light on the drug's mechanisms of action and its complex biological effects.

Original languageEnglish
Pages (from-to)19-20
Number of pages2
JournalCancer Biology and Therapy
Volume16
Issue number1
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • IMiDs
  • Thalidomide
  • angiogenesis
  • cereblon
  • immunomodulation
  • lenalidomide
  • pomalido- mide
  • teratogenesis
  • ubiquitin ligase

Fingerprint

Dive into the research topics of 'Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?'. Together they form a unique fingerprint.

Cite this