TY - JOUR
T1 - Successful long-term outcome after combined hematopoietic stem cell transplantation and small bowel transplantation
T2 - A case report and review of the literature
AU - Na, Sera
AU - Saldana, Blachy Davila
AU - Peredo-Pinto, Helka
AU - Gonzalez, Corina Elena
AU - Kroemer, Alexander Helmut
AU - Hawksworth, Jason
AU - Matsumoto, Cal Satoshi
AU - Yazigi, Nada
AU - Kaufman, Stuart
AU - Fishbein, Thomas Marlon
AU - Khan, Khalid
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Combining HSCT with SOT is an unusual and challenging undertaking given the complexities of immune modulation, the need to balance comorbidities, and the cumulative potential for complications. Early life-threatening complications include infections and related effects, graft rejection, and GVHD can be expected to be increased especially if the HSCT is indicated for high-risk cases such as individuals with severe combined immune deficiency and SOT that includes an intestine graft. Herein, we report such a case. Our patient is unique as a long-term survivor. We review the literature and the features of our case, especially the timing of transplants and human leukocyte antigen matching for HSCT that resulted in a successful outcome and discuss how this may be applied to others in the future.
AB - Combining HSCT with SOT is an unusual and challenging undertaking given the complexities of immune modulation, the need to balance comorbidities, and the cumulative potential for complications. Early life-threatening complications include infections and related effects, graft rejection, and GVHD can be expected to be increased especially if the HSCT is indicated for high-risk cases such as individuals with severe combined immune deficiency and SOT that includes an intestine graft. Herein, we report such a case. Our patient is unique as a long-term survivor. We review the literature and the features of our case, especially the timing of transplants and human leukocyte antigen matching for HSCT that resulted in a successful outcome and discuss how this may be applied to others in the future.
KW - graft-vs-host disease
KW - hematopoietic stem cell transplantation
KW - severe combined immune deficiency
KW - small bowel transplantation
UR - http://www.scopus.com/inward/record.url?scp=85071495212&partnerID=8YFLogxK
U2 - 10.1111/petr.13563
DO - 10.1111/petr.13563
M3 - Article
C2 - 31471935
AN - SCOPUS:85071495212
SN - 1397-3142
VL - 23
JO - Pediatric Transplantation
JF - Pediatric Transplantation
IS - 7
M1 - e13563
ER -