Successful renal transplantation in patients with chronic granulomatous disease

A. Bolanowski, R. B. Mannon, S. M. Holland, H. L. Malech, J. Aschan, J. Palmblad, D. A. Hale, A. D. Kirk*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Chronic granulomatous disease (CGD) is a genetic disease caused by structural mutations in the enzyme NADPH oxidase that results in severe immunodeficiency. End-stage renal disease occurs in this patient population, and is often attributed to the necessary use of nephrotoxic anti-infectives. In this report, we present the experiences of two centers in transplantation of three patients with CGD: one transplanted with CGD, one cured of his CGD with bone marrow transplantation who subsequently underwent kidney transplantation and one that received a kidney transplant prior to being cured of CGD via a sequential peripheral blood stem cell transplant (SCT). All three recipients have enjoyed excellent outcomes. Their courses demonstrate the absolute requirements for a multidisciplinary and compulsive approach before, during and after transplantation. These case reports also highlight the unexpectedly benign effects of immunosuppressive therapy in this patient population.

Original languageEnglish
Pages (from-to)636-639
Number of pages4
JournalAmerican Journal of Transplantation
Issue number3
StatePublished - Mar 2006
Externally publishedYes


  • Chronic granulomatous disease
  • Kidney
  • Transplant


Dive into the research topics of 'Successful renal transplantation in patients with chronic granulomatous disease'. Together they form a unique fingerprint.

Cite this