Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study

Edwin Kamau; Sidhartha Chaudhury; Jessica S. Bolton; Bonnie M. Slike; Ningbo Jian; Michael A. Eller; Leigh Anne Eller; Julie Ake; Merlin L. Robb; Shelly J. Krebs; Elke S. Bergmann-Leitner

doi:10.1093/cid/ciac384

Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study

Edwin Kamau^*, Sidhartha Chaudhury, Jessica S. Bolton, Bonnie M. Slike, Ningbo Jian, Michael A. Eller, Leigh Anne Eller, Julie Ake, Merlin L. Robb, Shelly J. Krebs, Elke S. Bergmann-Leitner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Human immunodeficiency virus (HIV) and malaria infection rates overlap across sub-Saharan Africa, but factors influencing their co-occurrence are unclear. In a case-control study, we investigated whether malaria exposure increases risk of type 1 (HIV-1) acquisition. Prior to seroconverting, HIV-positive cases had significantly higher malaria-associated antibodies compared to HIV-negative controls, linking malaria exposure to HIV-1 acquisition.

Original language	English
Pages (from-to)	1834-1837
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	75
Issue number	10
DOIs	https://doi.org/10.1093/cid/ciac384
State	Published - 15 Nov 2022
Externally published	Yes

Keywords

East Africa
HIV-1 acquisition
HIV-1 susceptibility
Thailand
malaria

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title = "Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study",

abstract = "Human immunodeficiency virus (HIV) and malaria infection rates overlap across sub-Saharan Africa, but factors influencing their co-occurrence are unclear. In a case-control study, we investigated whether malaria exposure increases risk of type 1 (HIV-1) acquisition. Prior to seroconverting, HIV-positive cases had significantly higher malaria-associated antibodies compared to HIV-negative controls, linking malaria exposure to HIV-1 acquisition.",

keywords = "East Africa, HIV-1 acquisition, HIV-1 susceptibility, Thailand, malaria",

author = "Edwin Kamau and Sidhartha Chaudhury and Bolton, {Jessica S.} and Slike, {Bonnie M.} and Ningbo Jian and Eller, {Michael A.} and Eller, {Leigh Anne} and Julie Ake and Robb, {Merlin L.} and Krebs, {Shelly J.} and Bergmann-Leitner, {Elke S.}",

year = "2022",

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doi = "10.1093/cid/ciac384",

language = "English",

volume = "75",

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TY - JOUR

T1 - Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure

T2 - A Case-Control Study

AU - Kamau, Edwin

AU - Chaudhury, Sidhartha

AU - Bolton, Jessica S.

AU - Slike, Bonnie M.

AU - Jian, Ningbo

AU - Eller, Michael A.

AU - Eller, Leigh Anne

AU - Ake, Julie

AU - Robb, Merlin L.

AU - Krebs, Shelly J.

AU - Bergmann-Leitner, Elke S.

PY - 2022/11/15

Y1 - 2022/11/15

N2 - Human immunodeficiency virus (HIV) and malaria infection rates overlap across sub-Saharan Africa, but factors influencing their co-occurrence are unclear. In a case-control study, we investigated whether malaria exposure increases risk of type 1 (HIV-1) acquisition. Prior to seroconverting, HIV-positive cases had significantly higher malaria-associated antibodies compared to HIV-negative controls, linking malaria exposure to HIV-1 acquisition.

AB - Human immunodeficiency virus (HIV) and malaria infection rates overlap across sub-Saharan Africa, but factors influencing their co-occurrence are unclear. In a case-control study, we investigated whether malaria exposure increases risk of type 1 (HIV-1) acquisition. Prior to seroconverting, HIV-positive cases had significantly higher malaria-associated antibodies compared to HIV-negative controls, linking malaria exposure to HIV-1 acquisition.

KW - East Africa

KW - HIV-1 acquisition

KW - HIV-1 susceptibility

KW - Thailand

KW - malaria

UR - http://www.scopus.com/inward/record.url?scp=85153380637&partnerID=8YFLogxK

U2 - 10.1093/cid/ciac384

DO - 10.1093/cid/ciac384

M3 - Article

C2 - 35594548

AN - SCOPUS:85153380637

SN - 1058-4838

VL - 75

SP - 1834

EP - 1837

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 10

ER -

Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study

Abstract

Keywords

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