Synthesis of a stable and orally bioavailable englerin analogue

David M. Fash, Cody J. Peer, Zhenwu Li, Ian J. Talisman, Sima Hayavi, Florian J. Sulzmaier, Joe W. Ramos, Carole Sourbier, Leonard Neckers, W. Douglas Figg, John A. Beutler*, William J. Chain

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.

Original languageEnglish
Pages (from-to)2641-2644
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
StatePublished - 1 Jun 2016
Externally publishedYes


  • Bioavailability
  • Cancer
  • Englerins
  • Sesquiterpenes


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