Tachykinin modulation of coronary blood flow

David Ezra; Francisco R.M. Laurindo; Jacob Eimerl; Robert E. Goldstein; Carl C. Peck; Giora Feuerstein

doi:10.1016/0014-2999(86)90169-X

Tachykinin modulation of coronary blood flow

David Ezra, Francisco R.M. Laurindo, Jacob Eimerl, Robert E. Goldstein, Carl C. Peck, Giora Feuerstein^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In pentobarbital anesthetized, open chest pigs, coronary blood flow (CBF), myocardial contractility and systemic hemodynamic variables were monitored during intracoronary injections of substance P (SP), neurokinin A (NA) or neurokinin B (NB). SP was most potent in increasing CBF although NA was also active in high doses while NB had absolutely no effect. SP was also more potent than NA in producing systemic hypotension. The data suggests that SP and its receptors might be potentially important modulators of CBF.

Original language	English
Pages (from-to)	135-138
Number of pages	4
Journal	European Journal of Pharmacology
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(86)90169-X
State	Published - 11 Mar 1986
Externally published	Yes

Keywords

Coronary blood flow
Neurokinin A
Neurokinin B
Neuropeptides
Substance P
Tachykinins

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10.1016/0014-2999(86)90169-X

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title = "Tachykinin modulation of coronary blood flow",

abstract = "In pentobarbital anesthetized, open chest pigs, coronary blood flow (CBF), myocardial contractility and systemic hemodynamic variables were monitored during intracoronary injections of substance P (SP), neurokinin A (NA) or neurokinin B (NB). SP was most potent in increasing CBF although NA was also active in high doses while NB had absolutely no effect. SP was also more potent than NA in producing systemic hypotension. The data suggests that SP and its receptors might be potentially important modulators of CBF.",

keywords = "Coronary blood flow, Neurokinin A, Neurokinin B, Neuropeptides, Substance P, Tachykinins",

author = "David Ezra and Laurindo, {Francisco R.M.} and Jacob Eimerl and Goldstein, {Robert E.} and Peck, {Carl C.} and Giora Feuerstein",

year = "1986",

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doi = "10.1016/0014-2999(86)90169-X",

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T1 - Tachykinin modulation of coronary blood flow

AU - Ezra, David

AU - Laurindo, Francisco R.M.

AU - Eimerl, Jacob

AU - Goldstein, Robert E.

AU - Peck, Carl C.

AU - Feuerstein, Giora

PY - 1986/3/11

Y1 - 1986/3/11

N2 - In pentobarbital anesthetized, open chest pigs, coronary blood flow (CBF), myocardial contractility and systemic hemodynamic variables were monitored during intracoronary injections of substance P (SP), neurokinin A (NA) or neurokinin B (NB). SP was most potent in increasing CBF although NA was also active in high doses while NB had absolutely no effect. SP was also more potent than NA in producing systemic hypotension. The data suggests that SP and its receptors might be potentially important modulators of CBF.

AB - In pentobarbital anesthetized, open chest pigs, coronary blood flow (CBF), myocardial contractility and systemic hemodynamic variables were monitored during intracoronary injections of substance P (SP), neurokinin A (NA) or neurokinin B (NB). SP was most potent in increasing CBF although NA was also active in high doses while NB had absolutely no effect. SP was also more potent than NA in producing systemic hypotension. The data suggests that SP and its receptors might be potentially important modulators of CBF.

KW - Coronary blood flow

KW - Neurokinin A

KW - Neurokinin B

KW - Neuropeptides

KW - Substance P

KW - Tachykinins

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AN - SCOPUS:0022448518

SN - 0014-2999

VL - 122

SP - 135

EP - 138

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Tachykinin modulation of coronary blood flow

Abstract

Keywords

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