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Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: Implications for the 8-aminoquinoline class of anti-malarial compounds

  • Sean R. Marcsisin*
  • , Jason C. Sousa
  • , Gregory A. Reichard
  • , Diana Caridha
  • , Qiang Zeng
  • , Norma Roncal
  • , Ronan McNulty
  • , Julio Careagabarja
  • , Richard J. Sciotti
  • , Jason W. Bennett
  • , Victor E. Zottig
  • , Gregory Deye
  • , Qigui Li
  • , Lisa Read
  • , Mark Hickman
  • , N. P.Dhammika Nanayakkara
  • , Larry A. Walker
  • , Bryan Smith
  • , Victor Melendez
  • , Brandon S. Pybus
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

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Pharmacology, Toxicology and Pharmaceutical Science