Targeted metagenomic assessment reflects critical colonization in battlefield injuries

Car Reen Kok, Nisha Mulakken, James B Thissen, Scott F Grey, Aram Avila-Herrera, Meenu M Upadhyay, Felipe A Lisboa, Shalini Mabery, Eric A Elster, Seth A Schobel, Nicholas A Be

Research output: Contribution to journalArticlepeer-review

Abstract

Microbial contamination in combat wounds can lead to opportunistic infections and adverse outcomes. However, current microbiological detection has a limited ability to capture microbial functional genes. This work describes the application of targeted metagenomic sequencing to profile wound bioburden and capture relevant wound-associated signatures for clinical utility. Ultimately, the ability to detect such signatures will help guide clinical decisions regarding wound care and management and aid in the prediction of wound outcomes.

Original languageEnglish
Pages (from-to)e0252023
JournalMicrobiology Spectrum
Volume11
Issue number6
Early online date24 Oct 2023
DOIs
StatePublished - 12 Dec 2023

Keywords

  • Wound Infection/diagnosis
  • Humans
  • War-Related Injuries/diagnosis
  • Metagenome

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