Targeting the host immune response for tissue engineering and regenerative medicine applications

Jenna L. Dziki, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Biomaterials and cells are essential components of almost every tissue-engineering approach for the repair or replacement of injured or missing tissue. Until recently, the host response to these materials and cells has been considered as a proinflammatory phenomenon to be suppressed to the extent possible. However, technological advances in immunolabeling, cell sorting, genomics, and proteomics among other laboratory techniques have revealed the essential roles of the immune system in tissue and organ development, homeostasis, and stem cell recruitment, proliferation, and differentiation; processes of interest and importance to tissue engineering (TE) and regenerative medicine. The present chapter reviews the role of individual immune cell in the context of TE and remodeling, specialized functions and signaling mechanisms of these immune cells, and current methods for manipulating immune cell activity to achieve better outcomes.

Original languageEnglish
Title of host publicationPrinciples of Tissue Engineering
PublisherElsevier
Pages363-368
Number of pages6
ISBN (Electronic)9780128184226
DOIs
StatePublished - 1 Jan 2020
Externally publishedYes

Keywords

  • Biomaterials
  • Host response
  • Immunomodulation
  • Regenerative medicine
  • Tissue engineering
  • Wound healing

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