Abstract
Biomaterials and cells are essential components of almost every tissue-engineering approach for the repair or replacement of injured or missing tissue. Until recently, the host response to these materials and cells has been considered as a proinflammatory phenomenon to be suppressed to the extent possible. However, technological advances in immunolabeling, cell sorting, genomics, and proteomics among other laboratory techniques have revealed the essential roles of the immune system in tissue and organ development, homeostasis, and stem cell recruitment, proliferation, and differentiation; processes of interest and importance to tissue engineering (TE) and regenerative medicine. The present chapter reviews the role of individual immune cell in the context of TE and remodeling, specialized functions and signaling mechanisms of these immune cells, and current methods for manipulating immune cell activity to achieve better outcomes.
| Original language | English |
|---|---|
| Title of host publication | Principles of Tissue Engineering |
| Publisher | Elsevier |
| Pages | 363-368 |
| Number of pages | 6 |
| ISBN (Electronic) | 9780128184226 |
| DOIs | |
| State | Published - 1 Jan 2020 |
| Externally published | Yes |
Keywords
- Biomaterials
- Host response
- Immunomodulation
- Regenerative medicine
- Tissue engineering
- Wound healing