TY - JOUR
T1 - Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model
AU - Stonko, David P.
AU - Rousseau, Mathieu C.
AU - Price, Colin
AU - Benike, Amy
AU - Treffalls, Rebecca N.
AU - Brunton, Nichole E.
AU - Rosen, Dorian
AU - Morrison, Jonathan J.
N1 - Publisher Copyright:
© 2024 Society for Vascular Surgery
PY - 2024/1
Y1 - 2024/1
N2 - Pressure-volume (PV) loop analysis is a sophisticated invasive approach to quantifying load-dependent and independent measures of cardiac function. Biventricular (BV) PV loops allow left and right ventricular function to be quantified simultaneously and independently, which is important for conditions and certain physiologic states, such as ventricular decoupling or acute physiologic changes. BV PV loops can be performed in an entirely endovascular, percutaneous, and closed-chest setting. This technique is helpful in a survival animal model, as a percutaneous monitoring system during endovascular device experiments, or in cases where chest wall compliance is being tested or may be a confounder. In this article, we describe the end-to-end implementation of a completely endovascular, totally percutaneous, and closed-chest large animal model to obtain contemporaneous BV PV loops in 40 to 70 kg swine. We describe the associated surgical and technical challenges and our solutions to obtaining endovascular BV PV loops, closed-chest cardiac output, and stroke volume (including validation of the correction factor necessary for thermodilution), as well as how to perform endovascular inferior vena cava occlusion in this swine model. We also include techniques for data acquisition and analysis that are required for this method.
AB - Pressure-volume (PV) loop analysis is a sophisticated invasive approach to quantifying load-dependent and independent measures of cardiac function. Biventricular (BV) PV loops allow left and right ventricular function to be quantified simultaneously and independently, which is important for conditions and certain physiologic states, such as ventricular decoupling or acute physiologic changes. BV PV loops can be performed in an entirely endovascular, percutaneous, and closed-chest setting. This technique is helpful in a survival animal model, as a percutaneous monitoring system during endovascular device experiments, or in cases where chest wall compliance is being tested or may be a confounder. In this article, we describe the end-to-end implementation of a completely endovascular, totally percutaneous, and closed-chest large animal model to obtain contemporaneous BV PV loops in 40 to 70 kg swine. We describe the associated surgical and technical challenges and our solutions to obtaining endovascular BV PV loops, closed-chest cardiac output, and stroke volume (including validation of the correction factor necessary for thermodilution), as well as how to perform endovascular inferior vena cava occlusion in this swine model. We also include techniques for data acquisition and analysis that are required for this method.
KW - Biventricular pressure-volume loops
KW - Closed-chest
KW - Endovascular
KW - LV PV loops
KW - RV PV loops
UR - http://www.scopus.com/inward/record.url?scp=85186417250&partnerID=8YFLogxK
U2 - 10.1016/j.jvssci.2024.100190
DO - 10.1016/j.jvssci.2024.100190
M3 - Article
AN - SCOPUS:85186417250
SN - 2666-3503
VL - 5
JO - JVS-Vascular Science
JF - JVS-Vascular Science
M1 - 100190
ER -