Tetracycline susceptibility testing and resistance genes in isolates of Acinetobacter baumannii-Acinetobacter calcoaceticus complex from a U.S. military hospital

Kevin S. Akers, Katrin Mende, Heather C. Yun, Duane R. Hospenthal, Miriam L. Beckius, Xin Yu, Clinton K. Murray

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Infections with multidrug-resistant Acinetobacter baumannii-Acinetobacter calcoaceticus complex bacteria complicate the care of U.S. military personnel and civilians worldwide. One hundred thirty-three isolates from 89 patients at our facility during 2006 and 2007 were tested by disk diffusion, Etest, and broth microdilution for susceptibility to tetracycline, doxycycline, minocycline, and tigecycline. Minocycline was the most active in vitro, with 90% of the isolates tested susceptible. Susceptibilities varied significantly with the testing method. The acquired tetracycline resistance genes tetA, tetB, and tetA(39) were present in the isolates.

Original languageEnglish
Pages (from-to)2693-2695
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number6
DOIs
StatePublished - Jun 2009

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