TGF-β family signaling in mesenchymal differentiation

Ingo Grafe, Stefanie Alexander, Jonathan R. Peterson, Taylor Nicholas Snider, Benjamin Levi, Brendan Lee, Yuji Mishina*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

189 Scopus citations


Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes.We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.

Original languageEnglish
Article numbera022202
JournalCold Spring Harbor Perspectives in Biology
Issue number5
StatePublished - May 2018
Externally publishedYes


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