TGF-β family signaling in mesenchymal differentiation

Ingo Grafe; Stefanie Alexander; Jonathan R. Peterson; Taylor Nicholas Snider; Benjamin Levi; Brendan Lee; Yuji Mishina

doi:10.1101/cshperspect.a022202

TGF-β family signaling in mesenchymal differentiation

Ingo Grafe, Stefanie Alexander, Jonathan R. Peterson, Taylor Nicholas Snider, Benjamin Levi, Brendan Lee, Yuji Mishina^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

251 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes.We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.

Original language	English
Article number	a022202
Journal	Cold Spring Harbor Perspectives in Biology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1101/cshperspect.a022202
State	Published - May 2018
Externally published	Yes

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title = "TGF-β family signaling in mesenchymal differentiation",

abstract = "Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes.We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.",

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AU - Grafe, Ingo

AU - Alexander, Stefanie

AU - Peterson, Jonathan R.

AU - Snider, Taylor Nicholas

AU - Levi, Benjamin

AU - Lee, Brendan

AU - Mishina, Yuji

PY - 2018/5

Y1 - 2018/5

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AB - Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes.We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.

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JO - Cold Spring Harbor Perspectives in Biology

JF - Cold Spring Harbor Perspectives in Biology

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TGF-β family signaling in mesenchymal differentiation

Abstract

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