Thalidomide metabolites. Part 1: Derivatives of (+)-2-(N-phthalimido)- γ-hydroxyglutamic acid

Frederick A. Luzzio; Alexander V. Mayorov; William D. Figg

doi:10.1016/S0040-4039(00)00160-X

Thalidomide metabolites. Part 1: Derivatives of (+)-2-(N-phthalimido)- γ-hydroxyglutamic acid

Frederick A. Luzzio^*, Alexander V. Mayorov, William D. Figg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A mild version of the Lemieux-Johnson olefin cleavage followed by a peroxide-mediated dialdehyde oxidation and esterification effected the conversion of 1-acyloxy-4-N-phthalimido-2-cyclopentenyl esters to γ- oxygenated-N-phthalimidoglutamic ester derivatives. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2275-2278
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	14
DOIs	https://doi.org/10.1016/S0040-4039(00)00160-X
State	Published - 1 Apr 2000
Externally published	Yes

Keywords

Amino acids and derivatives
Cleavage reactions
Imides
Osmylation
Oxidation

Access to Document

10.1016/S0040-4039(00)00160-X

Cite this

@article{94e973bcde1d46c8bf8bc4630ed5eb0c,

title = "Thalidomide metabolites. Part 1: Derivatives of (+)-2-(N-phthalimido)- γ-hydroxyglutamic acid",

abstract = "A mild version of the Lemieux-Johnson olefin cleavage followed by a peroxide-mediated dialdehyde oxidation and esterification effected the conversion of 1-acyloxy-4-N-phthalimido-2-cyclopentenyl esters to γ- oxygenated-N-phthalimidoglutamic ester derivatives. (C) 2000 Elsevier Science Ltd.",

keywords = "Amino acids and derivatives, Cleavage reactions, Imides, Osmylation, Oxidation",

author = "Luzzio, {Frederick A.} and Mayorov, {Alexander V.} and Figg, {William D.}",

year = "2000",

month = apr,

day = "1",

doi = "10.1016/S0040-4039(00)00160-X",

language = "English",

volume = "41",

pages = "2275--2278",

journal = "Tetrahedron Letters",

issn = "0040-4039",

number = "14",

}

TY - JOUR

T1 - Thalidomide metabolites. Part 1

T2 - Derivatives of (+)-2-(N-phthalimido)- γ-hydroxyglutamic acid

AU - Luzzio, Frederick A.

AU - Mayorov, Alexander V.

AU - Figg, William D.

PY - 2000/4/1

Y1 - 2000/4/1

N2 - A mild version of the Lemieux-Johnson olefin cleavage followed by a peroxide-mediated dialdehyde oxidation and esterification effected the conversion of 1-acyloxy-4-N-phthalimido-2-cyclopentenyl esters to γ- oxygenated-N-phthalimidoglutamic ester derivatives. (C) 2000 Elsevier Science Ltd.

AB - A mild version of the Lemieux-Johnson olefin cleavage followed by a peroxide-mediated dialdehyde oxidation and esterification effected the conversion of 1-acyloxy-4-N-phthalimido-2-cyclopentenyl esters to γ- oxygenated-N-phthalimidoglutamic ester derivatives. (C) 2000 Elsevier Science Ltd.

KW - Amino acids and derivatives

KW - Cleavage reactions

KW - Imides

KW - Osmylation

KW - Oxidation

UR - http://www.scopus.com/inward/record.url?scp=0034175596&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)00160-X

DO - 10.1016/S0040-4039(00)00160-X

M3 - Article

AN - SCOPUS:0034175596

SN - 0040-4039

VL - 41

SP - 2275

EP - 2278

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 14

ER -

Thalidomide metabolites. Part 1: Derivatives of (+)-2-(N-phthalimido)- γ-hydroxyglutamic acid

Abstract

Keywords

Access to Document

Fingerprint

Cite this