Thalidomide metabolites. Part 1: Derivatives of (+)-2-(N-phthalimido)- γ-hydroxyglutamic acid

Frederick A. Luzzio*, Alexander V. Mayorov, William D. Figg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A mild version of the Lemieux-Johnson olefin cleavage followed by a peroxide-mediated dialdehyde oxidation and esterification effected the conversion of 1-acyloxy-4-N-phthalimido-2-cyclopentenyl esters to γ- oxygenated-N-phthalimidoglutamic ester derivatives. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2275-2278
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number14
DOIs
StatePublished - 1 Apr 2000
Externally publishedYes

Keywords

  • Amino acids and derivatives
  • Cleavage reactions
  • Imides
  • Osmylation
  • Oxidation

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