TY - JOUR
T1 - The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference
T2 - Summary of breakout workshops
AU - Baqar, Shahida
AU - Bonavia, Aurelio
AU - Louis Bourgeois, A.
AU - Campo, Joseph J.
AU - Clifford, Allison
AU - Hanevik, Kurt
AU - Hasso-Agopsowicz, Mateusz
AU - Hausdorff, William
AU - Kaminski, Robert
AU - MacLennan, Calman A.
AU - Mantis, Nicholas
AU - Martin, Laura B.
AU - Omore, Richard
AU - Pasetti, Marcela
AU - Pavlinac, Patricia
AU - Phalipon, Armelle
AU - Poly, Frédéric
AU - Porter, Chad
AU - Ramasamy, Maheshi N.
AU - Rogawski McQuade, Elizabeth T.
AU - Sztein, Marcelo B.
AU - Walker, Richard
N1 - Publisher Copyright:
© 2023
PY - 2024/3/7
Y1 - 2024/3/7
N2 - The global public health nonprofit organization PATH hosted the third Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference in Washington, DC, from November 29 to December 1, 2022. This international gathering focused on cutting-edge research related to the development of vaccines against neglected diarrheal pathogens including Shigella, enterotoxigenic Escherichia coli (ETEC), Campylobacter, and non-typhoidal Salmonella. In addition to the conference's plenary content, the agenda featured ten breakout workshops on topics of importance to the enteric vaccine field. This unique aspect of VASE Conferences allows focused groups of attendees to engage in in-depth discussions on subjects of interest to the enteric vaccine development community. In 2022, the workshops covered a range of topics. Two focused on the public health value of enteric vaccines, with one examining how to translate evidence into policy and the other on the value proposition of potential combination vaccines against bacterial enteric pathogens. Two more workshops explored new tools for the development and evaluation of vaccines, with the first on integrating antigen/antibody technologies for mucosal vaccine and immunoprophylactic development, and the second on adjuvants specifically for Shigella vaccines for children in low- and middle-income countries. Another pair of workshops covered the status of vaccines against two emerging enteric pathogens, Campylobacter and invasive non-typhoidal Salmonella. The remaining four workshops examined the assessment of vaccine impact on acute and long-term morbidity. These included discussions on the nature and severity of intestinal inflammation; cellular immunity and immunological memory in ETEC and Shigella infections; clinical and microbiologic endpoints for Shigella vaccine efficacy studies in children; and intricacies of protective immunity to enteric pathogens. This article provides a brief summary of the presentations and discussions at each workshop in order to share these sessions with the broader enteric vaccine field.
AB - The global public health nonprofit organization PATH hosted the third Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference in Washington, DC, from November 29 to December 1, 2022. This international gathering focused on cutting-edge research related to the development of vaccines against neglected diarrheal pathogens including Shigella, enterotoxigenic Escherichia coli (ETEC), Campylobacter, and non-typhoidal Salmonella. In addition to the conference's plenary content, the agenda featured ten breakout workshops on topics of importance to the enteric vaccine field. This unique aspect of VASE Conferences allows focused groups of attendees to engage in in-depth discussions on subjects of interest to the enteric vaccine development community. In 2022, the workshops covered a range of topics. Two focused on the public health value of enteric vaccines, with one examining how to translate evidence into policy and the other on the value proposition of potential combination vaccines against bacterial enteric pathogens. Two more workshops explored new tools for the development and evaluation of vaccines, with the first on integrating antigen/antibody technologies for mucosal vaccine and immunoprophylactic development, and the second on adjuvants specifically for Shigella vaccines for children in low- and middle-income countries. Another pair of workshops covered the status of vaccines against two emerging enteric pathogens, Campylobacter and invasive non-typhoidal Salmonella. The remaining four workshops examined the assessment of vaccine impact on acute and long-term morbidity. These included discussions on the nature and severity of intestinal inflammation; cellular immunity and immunological memory in ETEC and Shigella infections; clinical and microbiologic endpoints for Shigella vaccine efficacy studies in children; and intricacies of protective immunity to enteric pathogens. This article provides a brief summary of the presentations and discussions at each workshop in order to share these sessions with the broader enteric vaccine field.
KW - Campylobacter
KW - Enteric diseases
KW - Enterotoxigenic Escherichia coli
KW - Invasive non-typhoidal Salmonella
KW - Shigella
KW - Vaccine development
UR - http://www.scopus.com/inward/record.url?scp=85178146010&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2023.11.045
DO - 10.1016/j.vaccine.2023.11.045
M3 - Article
C2 - 38036392
AN - SCOPUS:85178146010
SN - 0264-410X
VL - 42
SP - 1445
EP - 1453
JO - Vaccine
JF - Vaccine
IS - 7
ER -