The anti-apoptotic actions of nitric oxide in hepatocytes

Jianrong Li, Timothy R. Billiar*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

69 Scopus citations


Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.

Original languageEnglish
Pages (from-to)952-955
Number of pages4
JournalCell Death and Differentiation
Issue number10
StatePublished - Oct 1999
Externally publishedYes


  • Apoptosis
  • Caspases
  • Inducible NO synthase
  • S-nitrosylation


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