The anti-apoptotic actions of nitric oxide in hepatocytes

Jianrong Li; Timothy R. Billiar

doi:10.1038/sj.cdd.4400579

The anti-apoptotic actions of nitric oxide in hepatocytes

Jianrong Li, Timothy R. Billiar^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Short survey › peer-review

71 Scopus citations

Abstract

Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.

Original language	English
Pages (from-to)	952-955
Number of pages	4
Journal	Cell Death and Differentiation
Volume	6
Issue number	10
DOIs	https://doi.org/10.1038/sj.cdd.4400579
State	Published - Oct 1999

Keywords

Apoptosis
Caspases
Inducible NO synthase
S-nitrosylation

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10.1038/sj.cdd.4400579

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title = "The anti-apoptotic actions of nitric oxide in hepatocytes",

abstract = "Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.",

keywords = "Apoptosis, Caspases, Inducible NO synthase, S-nitrosylation",

author = "Jianrong Li and Billiar, {Timothy R.}",

note = "Funding Information: The research described in this review was supported by National Institutes of Health grants GM-44100 and GM-37753. J Li is supported by a postdoctoral fellowship from National Research Service Award GM19866.",

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AU - Billiar, Timothy R.

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N2 - Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.

AB - Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.

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KW - Caspases

KW - Inducible NO synthase

KW - S-nitrosylation

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The anti-apoptotic actions of nitric oxide in hepatocytes

Abstract

Keywords

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