The association of ethnicity with antibody responses to pneumococcal vaccination among adults with HIV infection

Nancy F. Crum-Cianflone*, Mollie Roediger, Kathy Huppler Hullsiek, Anuradha Ganesan, Michael Landrum, Amy Weintrob, Brian Agan, Sheila Medina, Jeremy Rahkola, Braden Hale, Edward N. Janoff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive disease. We evaluated the association of ethnicity with capsule-specific antibody responses to pneumococcal revaccination, with either the pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccines among 188 HIV-infected adults. The proportion of the 77 African Americans (AA) and 111 Caucasians with comparable virologic and immunologic parameters who achieved a positive immune response (≥2-fold rise in capsule-specific IgG from baseline with post-vaccination value ≥1μg/mL for ≥2 of 4 serotypes) at day 60 after revaccination was similar (43% vs. 49%, respectively, p=0.65). Results were also similar when vaccine types (PPV and PCV) were examined separately. Mean changes in log10 transformed IgG levels from baseline to days 60 and 180 post-vaccination were also not significantly different between AA and Caucasians. In summary, in this ethnically diverse cohort with equal access to care, we did not observe differential antibody responses between AA and Caucasian HIV-infected adults after pneumococcal revaccination.

Original languageEnglish
Pages (from-to)7583-7588
Number of pages6
Issue number48
StatePublished - 10 Nov 2010


  • Antibodies
  • Ethnicity
  • HIV
  • Pneumococcal vaccination


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