TY - JOUR
T1 - The association of ethnicity with antibody responses to pneumococcal vaccination among adults with HIV infection
AU - Crum-Cianflone, Nancy F.
AU - Roediger, Mollie
AU - Huppler Hullsiek, Kathy
AU - Ganesan, Anuradha
AU - Landrum, Michael
AU - Weintrob, Amy
AU - Agan, Brian
AU - Medina, Sheila
AU - Rahkola, Jeremy
AU - Hale, Braden
AU - Janoff, Edward N.
N1 - Funding Information:
Support for this work ( IDCRP RV-150 ) was provided by the Infectious Disease Clinical Research Program (IDCRP) , a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases , National Institutes of Health (NIH) , under Inter-Agency Agreement Y1-AI-5072 . Additional support was obtained from the Veterans Affairs Research Service.
PY - 2010/11/10
Y1 - 2010/11/10
N2 - Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive disease. We evaluated the association of ethnicity with capsule-specific antibody responses to pneumococcal revaccination, with either the pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccines among 188 HIV-infected adults. The proportion of the 77 African Americans (AA) and 111 Caucasians with comparable virologic and immunologic parameters who achieved a positive immune response (≥2-fold rise in capsule-specific IgG from baseline with post-vaccination value ≥1μg/mL for ≥2 of 4 serotypes) at day 60 after revaccination was similar (43% vs. 49%, respectively, p=0.65). Results were also similar when vaccine types (PPV and PCV) were examined separately. Mean changes in log10 transformed IgG levels from baseline to days 60 and 180 post-vaccination were also not significantly different between AA and Caucasians. In summary, in this ethnically diverse cohort with equal access to care, we did not observe differential antibody responses between AA and Caucasian HIV-infected adults after pneumococcal revaccination.
AB - Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive disease. We evaluated the association of ethnicity with capsule-specific antibody responses to pneumococcal revaccination, with either the pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccines among 188 HIV-infected adults. The proportion of the 77 African Americans (AA) and 111 Caucasians with comparable virologic and immunologic parameters who achieved a positive immune response (≥2-fold rise in capsule-specific IgG from baseline with post-vaccination value ≥1μg/mL for ≥2 of 4 serotypes) at day 60 after revaccination was similar (43% vs. 49%, respectively, p=0.65). Results were also similar when vaccine types (PPV and PCV) were examined separately. Mean changes in log10 transformed IgG levels from baseline to days 60 and 180 post-vaccination were also not significantly different between AA and Caucasians. In summary, in this ethnically diverse cohort with equal access to care, we did not observe differential antibody responses between AA and Caucasian HIV-infected adults after pneumococcal revaccination.
KW - Antibodies
KW - Ethnicity
KW - HIV
KW - Pneumococcal vaccination
UR - http://www.scopus.com/inward/record.url?scp=78249240066&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.09.056
DO - 10.1016/j.vaccine.2010.09.056
M3 - Article
C2 - 20887830
AN - SCOPUS:78249240066
SN - 0264-410X
VL - 28
SP - 7583
EP - 7588
JO - Vaccine
JF - Vaccine
IS - 48
ER -